Pediatric inherited cancer predisposition syndromes and TP53 germ-line mutation

  • TANG Yuejia ,
  • GAO Yijin
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  • Department of Hematology/Oncology, Shanghai Children’s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

Received date: 2016-05-15

  Online published: 2016-05-15

Abstract

Pediatric inherited cancer predisposition syndromes are a group of diseases caused by germ-line mutation of cancer related genes. The patients are susceptible to cancers. TP53 germ-line mutation is the most commonly seen mutant gene in cancers that accounts for 20%-30% of all germ-line mutations of inherited cancers. TP53 gene mutation screening could help clinicians to better manage the patients and their family members.

Cite this article

TANG Yuejia , GAO Yijin . Pediatric inherited cancer predisposition syndromes and TP53 germ-line mutation[J]. Journal of Clinical Pediatrics, 2016 , 34(5) : 333 . DOI: 10.3969 j.issn.1000-3606.2016.05.004

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