The role of retinoic acid receptor and its signal pathway in the renal disease

  • JIANG Ling
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  • Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China

Received date: 2016-03-15

  Online published: 2016-03-15

Abstract

Retinoic acid (RA) receptor, is a group of ligand-regulated nuclear transcription factors and widely distributed in various tissue cells. The different subtypes of RA receptor can polymerize into homologous or heterogenous dimmers, and then participate in the physiological and pathological processes of embryonic development, cell proliferation and differentiation, and apoptosis. However, the relationship between the expression of RA receptor and the diseases is different in diverse cells or tissues. Recent researches demonstrated that RA receptor is closely related to the pathogenesis and development of renal diseases. This article aims to review the role of the RA receptor and its signal pathway in the development of renal diseases.

Cite this article

JIANG Ling . The role of retinoic acid receptor and its signal pathway in the renal disease[J]. Journal of Clinical Pediatrics, 2016 , 34(3) : 227 . DOI: 10.3969 j.issn.1000-3606.2016.03.018

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