Objective To explore life quality of infants with eczema and their families before and after treatment. Methods The infants with eczema were divided into food allergic group (FA group, n=46) and non-food allergic group (N-FA group, n=47). The eczema was evaluated by the areas of eczema and severity index (EASI). After 2 months of standardized intervention, the quality of life before and after treatment were assessed by the Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF) and the Infant’s Dermatitis Quality of Life Index (IDQOL). Results There was no difference between the two groups in age, gender, family history of allergy and feeding patterns (all P ＞  0.05). In FA group, there were 34 cases (73.91%) of egg allergy, 20 cases (43.48%) of milk allergy and 2 cases (4.35%) of carrot allergy. After the intervention, the scores of EASI, FAQLQ, and IDQOL were decreased obviously in the two groups, and there were statistical difference before and after treatment ( P all < 0.05). Before treatment, the total score and each part of FAQLQ-PF in FA group was similar with N-FA group ( P all ＞  0.05); After two months of intervention, the total score of FAQLQ in FA group was higher than that in N-FA group (Z =2.83, P =0.005); the subscales of emotional impact, anxiety about food, and social/dietary restrictions were also significantly different between FA group and N-FA group (Z = 2.13-2.89, all P < 0.05). Conclusions Parents of infants with food allergies are more likely to worry about infant's emotional changes and social, dietary restrictions. FAQLQ-PF is more specific for assessing the quality of life in food allergies.