Polymorphism in signal transducer and activator of transcription 3 (STAT3) gene and susceptibility of epilepsy in children

  • WU Gefei ,
  • HU Jiasheng ,
  • ZHAO Peiwei ,
  • LIU Zhisheng ,
  • HE Xuelian ,
  • YUE Xin ,
  • WAN Chunhui
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  • 1 .Clinical Research Center, 2 .Department of Neurology, Wuhan Medical & Healthcare Center for Women and Children, Wuhan Children's Hospital, Wuhan 430016 , Hubei, China

Received date: 2016-11-15

  Online published: 2016-11-15

Abstract

 Objective To explore the association between two single nucleotide polymorphisms (SNP), rs1053005 and rs744166, in signal transducer and activator of transcription 3 (STAT3) gene and their susceptibility to childhood epilepsy. Methods A case control study was performed, in which 462 children with epilepsy including 121 children with intractable epilepsy were recruited. 493 healthy children were include as control group. PCR-RFLP was performed to investigate the two SNPs’ polymorphism. The relationship between the risk of children epilepsy and different genotypes and allelic genes was compared. Results Statistical differences of SNP rs1053005 genotype frequencies (AA, AG, GG) were found in epilepsy children as compared with control group ( χ2 =9.705, P =0.008). While the frequency of G allele in epilepsy children was obviously lower than that in the control group (OR =0.734, P =0.002, 95%CI: 0.604-0.892). There was no significant differences of SNP rs744166 genotype frequencies and C allele frequencies between epilepsy children and controls (P??>??0.05). Conclusion SNP rs1053005 of STAT3 gene was associated with the risk of childhood epilepsy.

Cite this article

WU Gefei , HU Jiasheng , ZHAO Peiwei , LIU Zhisheng , HE Xuelian , YUE Xin , WAN Chunhui . Polymorphism in signal transducer and activator of transcription 3 (STAT3) gene and susceptibility of epilepsy in children[J]. Journal of Clinical Pediatrics, 2016 , 34(11) : 801 . DOI: 10.3969/j.issn.1000-3606.2016.11.001

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