Research progress of calcium channels in the pathogenesis of pulmonary arterial hypertension

  • HUANG Zixu
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  • 1. Department of Cardiology, Shanghai Children’s Hospital, Shanghai Jiao Tong University, Shanghai 200062, China; 2. Departmont of Cardiology, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

Received date: 2016-11-15

  Online published: 2016-11-15

Abstract

Pulmonary arterial hypertension (PAH) is a group of severe and progressive diseases, and eventually leading to right heart failure even death. Pulmonary vasoconstriction, Pulmonary vascular remodeling , thrombosis, and vascular stiffness are the major causes for PAH. Numerous studies have shown that Ca2+ signal plays indispensable role in maintaining vascular tension and the regulation of vascular smooth muscle cell proliferation and apoptosis, and these processes are mainly mediated by calcium channels. This paper will focus on the advances of calcium channels in the pathogenesis of pulmonary arterial hypertension.

Cite this article

HUANG Zixu . Research progress of calcium channels in the pathogenesis of pulmonary arterial hypertension[J]. Journal of Clinical Pediatrics, 2016 , 34(11) : 861 . DOI: 10.3969/j.issn.1000-3606.2016.11.015

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