The ghrelin is an endogenous ligand of the growth hormone (GH) secretagogue receptor, which can regulate the secretion of GH, stimulate the appetite, adjust the energy metabolism, and improve the cardiovascular function. Children with congenital heart disease (CHD) usually suffered from malnutrition and growth retardation, which were connected with insufficiency of energy intake, poor absorption, and increase of nutritional requirement, anatomy and the changes of hemodynamics. Many infants with CHD gradually present ventricular dysfunction and growth restriction in their early childhood, which consequently lead to severe complications. Ghrelin is valuable in  the early detection of potential CHD, plays an important role in improving the state of malnutrition and protecting the cardiac function, and provides an important reference to explore the new drug therapy for CHD. This review summarized the effects and significances of ghrelin on growth and cardiac function in infants with CHD.