Analysis of hepatitis associated aplastic anemia in 5 children

  •  LI Xiang ,
  • SHENG Guangyao ,
  • ZHAO Xiaoming
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  • Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052 , Henan ,China

Received date: 2017-04-15

  Online published: 2017-04-15

Abstract

 Objective To explore the clinical feature, treatment and prognosis of hepatitis associated aplastic anemia (HAAA) in children. Method The clinical data of 5 children with HAAA were retrospectively analyzed. Results There were 5 patients (4 males and 1 female) with median age of 10 years (7~13 years ). The detection of hepatitis A, B, C, and E were all negative in these 5 children during their acute hepatitis period. In 2 children, parvovirus B19 antibody and EB virus were negative and the proportion of CD4+T cells and the ratio of CD4+/CD8+ were decreased, and the proportion of CD8+T cells was increased by T-lymphocyte subsets analysis. Three children were treated with anti-thymocyte globulin combined with cyclosporine, 2 of whom achieved complete remission and 1 died of pulmonary fungal infection. One child was treated with cyclosporine only and achieved partial remission. One child lost follow-up after giving up treatment. Conclusion HAAA in children can be caused by viral seronegative hepatitis, and usually has T lymphocyte immune disorders.  Immunosuppressive therapy is effective.

Cite this article

 LI Xiang , SHENG Guangyao , ZHAO Xiaoming . Analysis of hepatitis associated aplastic anemia in 5 children[J]. Journal of Clinical Pediatrics, 2017 , 35(4) : 256 . DOI: 10.3969/j.issn.1000-3606.2017.04.004

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