临床儿科杂志 ›› 2020, Vol. 38 ›› Issue (2): 146-.doi: 10.3969/j.issn.1000-3606.2020.02.016

• 综合报道 • 上一篇    下一篇

华法林在儿童患者中应用的单中心药物流行病学研究

徐静涵 1,顾智淳 2,李浩 1,3,施芳红 2, 张顺国 1   

  1. 1.上海交通大学医学院附属上海儿童医学中心药剂科;2.上海交通大学医学院附属仁济医院药剂科;  3.上海交通大学附属上海儿童医学中心临床研究中心(上海 200127)
  • 发布日期:2020-02-20
  • 通讯作者: 李浩,张顺国 电子信箱:lihao19880810@hotmail.com,zsguocn@sina.com
  • 基金资助:
    上海交通大学医学院附属上海儿童医学 中心院级科研基金项目(No.YJ-SCMC2018-11);上海交通大学中央高校基 本科研业务费资助项目(No.17JCYB11)

Single-center drug epidemiological study of warfarin in children

 XU jinghan1, GU zhichun2, LI Hao1,3, SHI Fanghong2, ZHANG Shunguo1   

  1. 1.Department of Pharmacy, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine; 2. Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine; 3. Clinical Research Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Published:2020-02-20

摘要:  目的 总结华法林在儿童患者中的应用情况。方法 回顾分析2014年1月至2018年12月接受华法林治疗的 362例患儿的临床资料并进行分析。结果 362例患儿中男性210例、女性152例,平均年龄5.9±4.7岁。患儿主要来源 于心胸外科(194例,53.6%)和心脏内科(125例,34.5%),所患疾病以先天性心脏病(242例,66.9%)和川崎病(74例, 20.4%)为主。主要来自华东地区(262例,72.4%)。 结论 华法林在儿童患者中的应用与成人患者有极大的不同,应特别 关注儿童的抗凝治疗和研究。

关键词: 华法林; 流行病学; 单中心; 儿童

Abstract: Objective To summarize the application of warfarin in children. Methods Clinical data of 362 children who used warfarin from January 2014 to December 2018 were collected and retrospectively analyzed. Results Among the 362 patients treated with warfarin, 210 (58.0%) were male patients and 152 (42.0%) were female patients. Of them 194 (53.6%) came from department of cardiothoracic surgery and 125 (34.5%) came from Department of Cardiology. Diseases needed warfarin therapy were mainly congenital heart disease (242 cases, 66.9%) and Kawasaki disease (74 cases, 20.4%). Pediatric patients treated with warfarin were mainly from East China (262 cases, 72.4%). Conclusion The use of warfarin in children is very different from that in adults. Children's anticoagulant therapy and research require special attention.

Key words: warfarin; epidemiology; single-center; child