临床儿科杂志 ›› 2020, Vol. 38 ›› Issue (9): 662-.doi: 10.3969/j.issn.1000-3606.2020.09.006

• 血液肿瘤疾病专栏 • 上一篇    

以高钙血症和骨质改变为首发表现的儿童急性淋巴细胞白血病1 例报告

吴崇军,熊婷,徐忠金   

  1. 江西省儿童医院 南昌大学附属儿童医院(江西南昌 330000)
  • 发布日期:2020-09-17
  • 通讯作者: 徐忠金 电子信箱:xuzhongjin691129@sina.com
  • 基金资助:
    江西省卫生计生委科技计划项目(No. 20185443);江西省重点研发计划项目 (No. 20181BBG78011)

Childhood acute lymphoblastic leukemia with hypercalcemia and bone changes as the first manifestation

 WU Chongjun, XIONG Ting, XU Zhongjin   

  1. Jiangxi Provincial Children's Hospital, The Affiliated Children's Hospital of Nanchang University, Nanchang 330000, Jiangxi, China
  • Published:2020-09-17

摘要: 目的 探讨以骨质改变和高钙血症为首发表现的儿童急性淋巴细胞白血病(ALL)的临床特点及诊治。方法 回顾分析1例以骨质改变和高钙血症为首发表现的儿童B细胞ALL的临床资料。结果 患儿,男性, 6岁5个月,以腹痛起 病,初期检查发现骨质改变及高钙血症,后确诊ALL。采用CCLG-ALL-2015方案化疗,同时加用伊马替尼口服,目前已获 得缓解。结论 高钙血症和骨质改变可以是B细胞ALL首发表现。

关键词: 急性淋巴细胞白血病; 骨质改变; 高钙血症; 儿童

Abstract:  Objective To explore the clinical features, diagnosis and treatment of childhood acute lymphoblastic leukemia (ALL) with bone changes and hypercalcemia as the first manifestation. Method The clinical data of childhood B-cell ALL with bone changes and hypercalcemia as the first manifestation were retrospectively analyzed. Results A boy, aged 6 years and 5 months old, started with abdominal pain. Bone changes and hypercalcemia were found at the initial examination, and ALL was confirmed later. The child was received oral administration of imatinib in addition to CCLG-ALL-2015 chemotherapy, and has been in remission. Conclusion Hypercalcemia and bone changes can be the first manifestation of B cell ALL

Key words: acute lymphocytic leukemia; bone changes; hypercalcemia; child