过敏性紫癜患儿血清IgA型抗内皮细胞抗体与细胞间黏附分子-1相关性初探

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (1): 12-14.

过敏性紫癜患儿血清IgA型抗内皮细胞抗体与细胞间黏附分子-1相关性初探

陈柏谕^* 杨光路^* 任少敏

内蒙古医科大学附属医院儿科（内蒙古呼和浩特　010059）

收稿日期:2013-08-08 出版日期:2014-01-15 发布日期:2014-01-15

Analysis of correlation between IgA-AECA and ICAM-1 in children with Henoch-Sch?nlein purpura　CHEN Baiyu, YANG Guanglu, REN Shaomin (Department of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia, China)

Received:2013-08-08 Online:2014-01-15 Published:2014-01-15

摘要/Abstract

摘要：

　目的　探讨过敏性紫癜（HSP）患儿血清IgA型抗内皮细胞抗体（IgA-AECA）与细胞间黏附分子-1（ICAM-1）水平及其相关性。方法　36例HSP患儿，其中26例无肾损害（HSP组），10例紫癜性肾炎（HSPN组），采用酶联免疫吸附法检测并比较血清IgA-AECA及ICAM-1的表达水平。结果　与HSP组相比，HSPN组IgA-AECA及ICAM-1的表达水平均显著增高，差异有统计学意义（P<0.01）；IgA-AECA与ICAM-1呈显著正相关（r=0.746，P<0.01）。结论　IgA-AECA可能作为HSP患儿ICAM-1高表达的始动因素，在疾病发展过程中起重要作用。

Abstract: 　Objectives　To detect the levels of anti-endothelial cell IgA antibodies (IgA-AECA) and intercellular adhesion molecule-1 (ICAM-1) in children with Henoch-Sch?nlein purpura, and to analyze the correlation between IgA-AECA and ICAM-1. Methods A total of 36 children with HSP were enrolled， 26 without renal impairment (HSP group), and 10 with renal impairment (HSPN). The concentrations of IgA-AECA and ICAM-1 in serum were detected by enzyme linked immunosorbent assay (ELISA). Results The serum levels of IgA-AECA and ICAM-1 in HSPN group were significantly higher than those in HSP group (P<0.01). The serum level of IgA-AECA showed positive correlation with the level of ICAM-1 (r=0.746, P<0.01). Conclusions IgA-AECA may play an important role in the development of HSP and HSPN by up-regulating the express of ICAM-1.

陈柏谕杨光路任少敏. 过敏性紫癜患儿血清IgA型抗内皮细胞抗体与细胞间黏附分子-1相关性初探[J]. 临床儿科杂志, 2014, 32(1): 12-14.

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