过敏性紫癜患儿血清中过氧化氢酶、对氧磷酶、丙二醛水平及意义

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (1): 4-7.

过敏性紫癜患儿血清中过氧化氢酶、对氧磷酶、丙二醛水平及意义

吴丽娟刘翠华田明

郑州市儿童医院肾脏风湿科（河南郑州　450000）

收稿日期:2014-01-15 出版日期:2014-01-15 发布日期:2014-01-15

Predictive value of catalase, paraoxonase, malondialdehyde level for children with Henoch-Sch?nlein purpura　WU Lijuan, LIU Cuihua, TIAN Ming (Department of Kidney and Rheumatology, The Children's Hospital of Zhengzhou, Zhengzhou 450000, Henan, China)

Received:2014-01-15 Online:2014-01-15 Published:2014-01-15

摘要/Abstract

摘要：

　目的　探讨过敏性紫癜（HSP）患儿血清中过氧化氢酶（CAT）、对氧磷酶（PON）、丙二醛（MDA）水平及其对HSP肾病的意义。方法　选取2009年4月至2011年10月诊断为HSP患儿47例，另选取20例正常儿童作为对照组。检测及比较两组儿童CAT、PON、MDA等指标，并分析HSP患儿CAT、PON及MDA水平与其蛋白尿的相关性。结果　HSP患儿的CAT和PON均低于对照组，而MDA水平则高于对照组，差异均有统计学意义（P均<0.05）。HSP伴有血尿或蛋白尿的患儿CAT和PON水平均较无血尿或蛋白尿患儿低，而伴有蛋白尿HSP患儿MDA水平高于无蛋白尿HSP患儿，差异均有统计学意义（P<0.05）。HSP患儿的血清CAT、PON水平与蛋白尿之间存在显著负相关（r=-0.674、-0.647，P均<0.05）；MDA水平与蛋白尿之间存在显著正相关（r=0.659，P<0.05）。结论　HSP患儿血清中CAT、PON水平显著下降，而MDA水平显著升高，可作为HSP肾病严重性的评估指标。

Abstract: 　Objective　To investigate the significance of serum catalase (CAT), paraoxonase (PON) and malondialdehyde (MDA) in children with Henoch-Sch?nlein purpura (HSP). Methods A total of 47 children with HSP were selected from April 2009 to October 2011, meanwhile 20 healthy children were selected as normal controls. The serum CAT, PON, MDA were detected and compared between two groups, and the association of CAT, PON and MDA levels with urine protein levels were analyzed in children with HSP. Results In children with HSP, the levels of CAT and PON were significantly lower and MDA levels were significantly higher than those in the control group (P<0.05). HSP patients with hematuria or proteinuria had significantly lower levels of CAT and PON than those without hematuria or proteinuria, while HSP patients with proteinuria have significantly higher level of MDA than those without proteinuria (P<0.05). In children with HSP, the serum levels of CAT and PON were negatively correlated with urine protein levels (r=-0.674, -0.647, P<0.05) while MDA level was positively correlated with urine protein levels (r=-0.659, P<0.05). Conclusions The levels of CAT and PON were decreased and MDA was increased in children with HSP, and so they can be used to evaluate the severity of nephropathy.

吴丽娟刘翠华田明. 过敏性紫癜患儿血清中过氧化氢酶、对氧磷酶、丙二醛水平及意义[J]. 临床儿科杂志, 2014, 32(1): 4-7.

参考文献

[1] Yilmaz A，Emre S，Agachan B，et al. Effect of paraoxonase 1 gene polymorphisms on clinical course of henoch-sch?nlein purpura [J]. J Nephrol，2009，22(6)：726-732.
[2] Nowak M，Helleboid-Chapman A，Jakel H，et al. Glucose regulates the expression of the apolipoprotein A5 gene [J]. J Mol Biol，2008，380(5)：789-798.
[3] Ece A，Kelekci S，Hekimoglu A，et al. Neutrophil activation，protein oxidation and ceruloplasmin levels in children with henoch-sc?nlein purpura [J]. Pediatr Nephrol，2007，22(8)：1151-1157.
[4] Erdogan O，Oner A，Aydin A，et al. Effect of vitamin e treatment on the oxidative damage occurring in henoch-sch?nlein purpura [J]. Acta Paediatr，2003，92(5)：546-550.
[5] 胡亚美，江载芳. 诸福棠实用儿科学［M］. 7版. 北京：人民卫生出版社，2002：688-690.
[6] Keskin N，Civilibal M，Elevli M，et al. Elevated plasma advanced oxidation protein products in children with henoch-sch?nlein purpura [J]. Pediatr Nephrol，2011，26(11)：1989-1993.
[7] Chen T，Guo ZP，Zhang YH，et al. Elevated serum heme oxygenase-1 and insulin-like growth factor-1 levels in patients with henoch-sch?nlein purpura [J]. Rheumatol Int，2011，31(3)：321-326.
[8] Zou C，Lu F，Mao W，et al. Chinese herbal medicine dans-hen formulations for preventing renal disease in henoch-sch?nlein purpura： A systematic review and meta-analysis [J]. J Altern Complement Med，2012，18(4)：394-401.
[9] Zhou TB，Ou C，Qin YH，et al. A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and henoch-sch?nlein purpura nephritis risk in asian children [J]. Clin Exp Rheumatol，2012，30(2)：315-316.
[10] Demircin G，Oner A，Unver Y，et al. Erythrocyte superoxide dismutase activity and plasma malondialdehyde levels in children with Henoch-Sch?nlein purpura [J]. Acta Pediatr，1998，87(8)：848-852.
[11] Tabel Y，Inanc FC，Dogan DG，et al. Clinical features of children with henoch-sch?nlein purpura： risk factors associated with renal involvement [J]. Iran J Kidney Dis，2012，6(4)：269-274.
[12] Minuz P，Fava C，Cominacini L. Oxidative stress，antioxidants，and vascular damage [J]. Br J Clin Pharmacol，2006，61(6)：774-777.
[13] Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions [J]. Clin Biochem，2004，37(2)：112-119.
[14] 姜红，王淑兰，王若梅，等. 过敏性紫癜患儿脂质过氧化及抗氧化的研究 [J]. 中华儿科杂志，1997，35(12)：663-664.
[15] 陈涛，郭在培，张宇虹，等. 过敏性紫癜患者血清丙二醛、总抗氧化能力和黄嘌呤氧化酶检测及意义[J]. 临床皮肤科杂志，2009，38(10) ：622-624.
（收稿日期：2013-06-14）