学龄期肥胖儿童肝X受体与脂代谢异常的相关性分析

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (2): 147-150.

学龄期肥胖儿童肝X受体与脂代谢异常的相关性分析

朱庆龄^{1, 2}, 叶新华², 杨声坪^{1, 2}, 刘倩^{1, 2}, 陈虹^{1, 2}

1.兰州大学第一临床医学院（甘肃兰州　730000）；2.兰州大学第一医院（甘肃兰州　730000）

收稿日期:2013-07-01 出版日期:2014-02-15 发布日期:2014-02-15

Correlation of liver X receptor and abnormal lipid metabolism in school-age children with obesity

ZHU Qingling^1,2, YE Xinhua², YANG Shengping^1,2, LIU Qian^1,2, CHEN Hong^1,2

(1.The First Clinical Medicine College of Lanzhou University; 2.The First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China)

Received:2013-07-01 Online:2014-02-15 Published:2014-02-15

摘要/Abstract

摘要：

　目的　探讨学龄期肥胖儿童肝X受体（LXR）与血脂代谢异常的相关因素。方法　自2011年6月至10月，在1~6年级学生（7~14岁）中，通过体格发育指标检测，筛选出80例肥胖儿童和51例年龄与性别匹配的正常对照儿童作为研究对象。取空腹静脉血进行天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、谷氨酰转肽酶（GGT）、总胆固醇（CHOL）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和LXR相对表达量检测。结果　肥胖儿童LXR表达量为（9.14±1.15），高于正常对照儿童的（2.84±3.68），差异有统计学意义（t=4.55，P=0.000）；肥胖儿童中LXR＞1比例为80.0%（64/80），高于正常对照儿童的45.1%（23/51），差异有统计学意义（χ²=17.01，P=0.000）。肥胖儿童的AST、ALT、GGT、CHOL、TG、LDL-C较正常对照儿童高，而HDL-C较正常对照儿童低，差异均有统计学意义（P<0.05）。LXR表达与AST、ALT、CHOL、LDL-C和BMI水平均呈正相关（r=0.18~0.26，P均<0.05）。AST≥40 IU/L （OR=1.076），ALT≥40 IU/L （OR=1.036），CHOL≥5.20 mmol/L （OR=2.038），LDL-C≥3.36 mmol/L （OR=2.176）、BMI≥18.9 kg/m² （OR=1.131）均为LXR＞1的危险因素（P均<0.05）。结论　学龄期儿童肥胖可能促使体内LXR的表达量上调，导致肝损伤和血脂紊乱。

Abstract: 　Objectives　To explore the relevant factors of liver X receptor (LXR) and lipid metabolism in school-age children with obesity. Methods A total of 80 obese children were selected by indexes of physical growth from pupils in Grades 1-6, aged 7-14 years from June 2011 to October 2011. Fifty-one age and sex matched children with normal BMI were chosen as normal controls. The metabolic indexes including aspartate transaminase (AST), alanine aminotransferase (ALT), glutamyl transpeptidase (GGT), total cholesterol (CHOL), triacylglycerol (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and expression of LXR were detected in fasting blood. Results The expression level of LXR in obese children (9.14±1.15) was higher than that in control children (2.84±3.68) with significant difference (t=4.55，P=0.000). Eighty percent (80%) of obese children were LXR> 1 (64/80) which was higher than that of control children (23/51, 45.1%), and significant difference was found between the two groups (χ²=17.01, P=0.000). Compared to controls, the levels of AST, ALT, GGT, CHOL, TG and LDL-C were higher while the level of HDL-C was lower in obese children (P<0.05). The correlation analysis found that AST, ALT, CHOL, LDL-C and BMI were positively correlated with LXR (r=0.18~0.26，P<0.05). Logistic regression ana-lysis showed that AST ≥40IU/L (OR=1.076), ALT≥40IU/L (OR=1.036), CHOL ≥5.20 mmol/L (OR=2.038), LDL-C ≥3.36 mmol/L (OR=2.176) and BMI ≥18.9 kg/m² (OR=1.131) were risk factors for LXR>1 (P<0.05). Conclusions Obesity in school-age children can up-regulate the expression of liver X receptor and cause liver damage and abnormal lipids metabolism.

朱庆龄, 叶新华, 杨声坪, 刘倩, 陈虹. 学龄期肥胖儿童肝X受体与脂代谢异常的相关性分析[J]. 临床儿科杂志, 2014, 32(2): 147-150.

ZHU Qingling,YE Xinhua,YANG Shengping,LIU Qian,CHEN Hong,. Correlation of liver X receptor and abnormal lipid metabolism in school-age children with obesity [J]. , 2014, 32(2): 147-150.

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