促性腺激素治疗对多种垂体激素缺乏症男性患者睾丸形态和功能影响的时效性

摘要/Abstract

摘要：

　目的　研究人绒毛膜促性腺激素（hCG）和人绝经期促性腺激素（hMG）起始治疗年龄对多种垂体激素缺乏症男性患者的睾丸形态和功能改善情况的影响。方法　以多种垂体激素缺乏症男性患者为研究对象，给予hCG和hMG治疗，同时维持其他激素正常，观察睾丸、阴茎形态，促性激素水平，身高，骨龄等变化值与开始治疗年龄的相关性。结果　入组的54例患者经hCG和hMG治疗6个月后，阴茎长度由治疗前的（2.58±0.69）cm增长至（4.19±0.77）cm，阴茎周长由治疗前的（3.71±1.36）cm增长至（5.95±1.26）cm，睾丸容积从治疗前的（1.76±1.49）ml增加至（5.20±2.30）ml，身高从治疗前的（147.01±12.29）cm增加至（151.98±11.52）cm，骨龄从治疗前的（11.22±2.71）岁增长至（11.64±2.72）岁，差异均有统计学意义（P<0.01）。睾丸容积及睾酮水平在治疗前、后的增长值随年龄增长均呈降低趋势，在各年龄组间的差异均有统计学意义（P均<0.05）。用药前后睾丸容积增长值、血清促卵泡激素（FSH）和黄体生成素（LH）水平增加值以及用药前后身高增长值均与开始治疗年龄呈负相关（r=-0.517~-0.334，P<0.05）。结论　在正常青春期时期适当早期给予多种垂体激素缺乏症男性患者hCG和hMG治疗可更好改善其第二性征和睾丸功能。

Abstract: 　Objectives　To study the impact of initial age of treatment on testicular morphology and function in male patients with multiple pituitary hormone deficiency using human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG). Methods Patients with multiple pituitary hormone deficiency were treated with hCG and hMG while keeping other hormone levels normal. Correlations among their testicular volume, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and height, bone age were analyzed. Results After 6-month hCG and hMG treatment, the penis length of 54 male patients was significantly increased from (2.58±0.69) cm to (4.19±0.77) cm , and penis circumference was also increased from (3.71 ± 1.36) cm to (5.95 ± 1.26) cm; the testicular volume was increased from (1.76 ± 1.49) ml to (5.20±2.30) ml; height was increased from (147.01 ± 12.29) cm to (151.98 ± 11.52) cm and bone age was increased from (11.22 ± 2.71) years to (11.64 ± 2.72) years; the differences before and after treatment were statistically significant (all P <0.01). As the patients' age increased, their testicular volume and testosterone level increased slowly, and significant differences amongst each age group were found (P<0.05). The increased value of testicular volume, serum FSH and LH levels, and height growth tended to be negatively correlated to the initial age of therapy (r=－0.517~－0.334, P<0.05). Conclusions Early and proper treatment in male patients with multiple pituitary hormone deficiency using hCG and hMG improves testicular function and secondary sex characteristics.

唐琳, 李桂梅, 王倩. 促性腺激素治疗对多种垂体激素缺乏症男性患者睾丸形态和功能影响的时效性[J]. 临床儿科杂志, 2014, 32(2): 151-155.

TANG Lin,LI Guimei,WANG Qian. Efficacy of hCG and hMG on testicular morphology and function in male patients with multiple pituitary hormone deficiency[J]. , 2014, 32(2): 151-155.

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