乳铁蛋白联合标准疗法治疗儿童幽门螺杆菌感染的疗效

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (4): 309-311.

乳铁蛋白联合标准疗法治疗儿童幽门螺杆菌感染的疗效

王艳丽¹, 李春力², 庄探月², 程艳波¹

1.郑州市第一人民医院儿科（河南郑州　450003）；2. 郑州人民医院儿科（河南郑州　450053）

收稿日期:2013-07-31 出版日期:2014-04-15 发布日期:2014-04-15

Effect of lactoferrin supplementation combined with standard therapy on Helicobacter pylori infection in children　WANG Yanli¹, LI Chunli², ZHUANG Tanyue², CHENG Yanbo¹ (1. Department of Pediatrics, The First People's Hospital of Zhengzhou, Zhengzhou 450003, henan, China; 2. Department of Pediatrics, The People's Hospital of Zhengzhou, Zhengzhou 450053, Henan, China)

Received:2013-07-31 Online:2014-04-15 Published:2014-04-15

摘要/Abstract

摘要：

　目的　观察乳铁蛋白联合幽门螺杆菌（H.pylori）标准三联疗法对儿童H.pylori感染根除率的影响及其不良反应。方法　将2012年1月至2013年1月确诊且未接受过根除治疗的H.pylori感染患儿90例随机分为两组，对照组45例接受标准三联疗法治疗，观察组45例在接受标准三联疗法同时联合应用乳铁蛋白，记录治疗过程中的不良反应，以及疗程结束后4周的H.pylori根除率。结果　观察组H.pylori根除率为（91.11%，41/45），高于对照组的根除率（73.33%，33/45）；观察组不良反应率为（4.44%，2/45），低于对照组的不良反应率（20.00%，9/45），差异均有统计学意义（P均<0.05）。结论　乳铁蛋白能提高H.pylori根除率，减少不良反应的发生。

Abstract: 　Objective　To observe the effect of lactoferrin supplementation combined with standard triple therapy on eradication rate of Helicobacter pylori (H.pylori) and its adverse reaction in children. Methods A total of 90 children who were diagnosed with H.pylori infection from January 2012 to January 2013 and had never received eradicative treatment were randomly divided into two groups. Forty-five children in control group received the standard triple therapy and another 45 children in observation group received lactoferrin supplementation combined with standard triple therapy. Adverse reaction during the treatment was recorded and eradication rate of H.pylori at 4 weeks after treatment was observed. Results The eradication rate of H.pylori in observation group (91.11%, 41/45) was higher than that in control group (73.33%, 33/45) and the adverse reaction rate in observation group (4.44%, 2/45) was lower than that in control group (20.00%, 9/45).The differences were significant (P<0.05). Conclusions Lactoferrin supplementation combined with standard triple therapy can increase H.pylori eradication rate and reduce the occurrence of adverse reaction.

王艳丽, 李春力, 庄探月, 程艳波. 乳铁蛋白联合标准疗法治疗儿童幽门螺杆菌感染的疗效[J]. 临床儿科杂志, 2014, 32(4): 309-311.

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