儿童孤独症多巴胺转运体脑显像研究

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (4): 323-325.

儿童孤独症多巴胺转运体脑显像研究

霍健，苏兴利，王爽

西安医学院基础医学研究所（陕西西安　710021）

收稿日期:2013-11-11 出版日期:2014-04-15 发布日期:2014-04-15

Dopamine transporter brain imaging in children with autism

HUO Jian, SU Xingli, WANG Shuang

(Fundamental Medical Institute, Xi'an Medical University, Xi'an 710021, Shaanxi, China)

Received:2013-11-11 Online:2014-04-15 Published:2014-04-15

摘要/Abstract

摘要：

　目的　通过单光子发射型计算机体层扫描技术（SPECT）研究孤独症儿童脑内多巴胺转运体（DAT）分布。方法　对10例孤独症儿童和10例正常对照儿童进行脑SPECT显像，计算并比较脑内不同功能区DAT的半定量值。结果　两组儿童纹状体区域的DAT半定量值左、右两侧差异均无统计学意义（P=0.556、0.563）；孤独症儿童的DAT半定量值明显高于对照儿童，差异有统计学意义（P=0.018）。结论　孤独症儿童脑内多巴胺能神经元活动亢进，SPECT可能有助于儿童孤独症诊断。

Abstract: Objective　To study the distribution of brain dopamine transporter (DAT) in children with autism by single photon emission computed tomography (SPECT). Methods Brain SPECT imaging was performed in 10 autistic children and 10 normal children, and DAT distribution in different functional areas of brain were calculated and compared by semi-quantitative evaluation of tracer uptake. Results There were no differences in tracer uptake between left and right striatum either in autistic children or in normal children (P=0.556, 0.563), while the tracer uptake level in autistic children was significantly higher than that in normal children (P=0.018). Conclusions The striatum dopaminergic neurons are hyperactive in children with autism. SPECT is helpful for the diagnosis of autism.

霍健，苏兴利，王爽. 儿童孤独症多巴胺转运体脑显像研究[J]. 临床儿科杂志, 2014, 32(4): 323-325.

HUO Jian,SU Xingli,WANG Shuang . Dopamine transporter brain imaging in children with autism [J]. , 2014, 32(4): 323-325.

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