儿童单核细胞增多性李斯特菌脑膜炎1例报告

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (4): 352-354.

儿童单核细胞增多性李斯特菌脑膜炎1例报告

吕勇，王书书

安徽医科大学附属安徽省立医院儿科（安徽合肥　230001）

收稿日期:2013-07-28 出版日期:2014-04-15 发布日期:2014-04-15

Listeria monocytogenes meningitis in a child: a case report

　LU Yong, WANG Shushu

(Department of Pediatrics, The Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, Anhui, China)

Received:2013-07-28 Online:2014-04-15 Published:2014-04-15

摘要/Abstract

摘要：

　目的　总结单核细胞增多性李斯特菌（LM）脑膜炎患儿的临床特点及治疗转归。方法　回顾性分析1例诊断为LM脑膜炎患儿的临床资料，并查阅文献。结果　本例患儿以发热、头痛、呕吐起病，经阿莫西林/克拉维酸钾及头孢曲松抗感染治疗有效，脑脊液及血培养均为LM生长。查阅到17篇相关文献，共24例患儿，其中4例死亡，10例发生脑积水等，氨苄西林或联合使用氨基糖苷类抗生素治疗有效。结论　LM脑膜炎在免疫功能正常儿童发生率低，但病死率及后遗症发生率高。脑脊液和血培养有助于诊断。

Abstract: Objective The clinical characteristics and treatment outcomes of Listeria monocytogenes (LM) meningitis were reviewed. Methods The clinical data of a case of LM meningitis were retrospectively analyzed and a literature review was performed. Results The child initially presenting with fever, headache and vomit was treated with amoxicillin/clavulanic acid and ceftriaxone and the treatment effect was obvious. Cerebrospinal fluid and blood cultures were LM positive. In 17 related articles, a total of 24 children with LM meningitis were reviewed. Among them, 4 patients died and 10 had hydrocephalus. The treatment with either ampicillin alone or in combination with aminoglycoside was effective. Conclusions LM meningitis was rare in immunocompetent children, but has high rates of mortality and sequelae.

吕勇，王书书. 儿童单核细胞增多性李斯特菌脑膜炎1例报告[J]. 临床儿科杂志, 2014, 32(4): 352-354.

　LU Yong,WANG Shushu. Listeria monocytogenes meningitis in a child: a case report[J]. , 2014, 32(4): 352-354.

参考文献

[1] 江玲丽，陈健舜，方维焕. 单核细胞增多性李斯特菌毒力因子研究进展 [J]. 中国人畜共患病杂志，2007，7（8）：733-735.
[2] Posfay-Barbe KM，Wald ER. Listeriosis [J]. Pediatr Rev，2004，25(5)：151-159.
[3] Crouzet-Ozenda1 L，Haas H，Bingen E，et al. Listeria monocytogenes meningitis in children in France [J]. Arch Pediatr，2008，15(Suppl 3)：S158-S160.
[4] Tim MW，Jackson MA，Shannon K，et al. Non-neonatal infection due to Listeria monocytogenes [J]. Pediatr Infect Dis，1984，3(3)：213-217.
[5] von Kalckreuth G，Staab D，Haverkamp F，et al. Listeria meningoencephalitis in a 2-year-old boy [J]. Monatsschr Kinderheilkd，1990，138(6)：351-353.
[6] Schneeberger P，Sluiter E，van Doorn LJ，et al. Listeria meningitis during treatment of a meningococcal meningitis in an immunocompetent infant [J]. Scand J Infect Dis，1996，28(5)：525-526.
[7] Economou M，Karyda S，Kansouzidou A，et al. Listeria meningitis in children：report of two cases [J]. Infection，2000，28(2)：121-123.
[8] Hitomi S，Ohto T，Okamoto M，et al. A case of Listerial meningitis treated with a regimen containing panipenem-betamipron [J]. J Infect Chemother，2004 ，10(4)：242-244.
[9] Ulloa-Gutierrez R，Avila-Aguero ML，Huertas E. Fulminant Listeria monocytogenes meningitis complicated with acute hydrocephalus in healthy children beyond the newborn pe-riod [J]. Pediatr Emerg Care，2004，20(4)：233-237.
[10] Flodrops H，Houdon L，Gerardin P，et al. Lymphocytis meningitis：Listeria monocytogenes is a potential risk in a immunocompetent child [J]. Arch Pediatr，2005，12(11)：1620-1623.
[11] Antal EA，L?berg EM，Dietrichs E，et al. Neuropathological findings in 9 cases of Listeria monocytogenes brain stem encephalitis [J]. Brain Pathol，2005 ，15(3)：187-191.
[12] Thabet F，Tilouche S，Tabarki B，et al. Listeria monocytogenes meningitis in an immunocompetent child [J]. Arch Pediatr，2006，13(12)：1553-1554.
[13] Pattarino G，Arrigoni S，Grazioli R，et al. A case of Listeria monocytogenes meningitis in an immunocompetent infant [J]. Minerva Pediatr，2006，58(4)：391-394.
[14] Dilber E，Aksoy A，Cakir M，et al. Listeria monocytogenes meningitis in two immunocompetent children [J]. Ann Trop Paediatr，2009，29(3)：225-229.
[15] Lee JE，Cho WK，Nam CH，et al. A case of meningoencephalitis caused by Listeria monocytogenes in a healthy child [J]. Korean J Pediatr，2010，53(5)：653-656.
[16] Peer MA，Nasir RA，Kakru DK，et al. Listeria monocytogenes meningoencephalitis in an immunocompetent，previously healthy 20-month old female child [J]. Indian J Med Microbiol，2010，28(2)：169-171.
[17] Montejo Ganan I，Romera Santabarbara B，Garcia Iniguez JP，et al. Acute encephalopathy，hydrocephalus and central diabetes insipidus as the first signs of Listeria monocytogenes meningitis [J]. An Pediatr (Barc)，2010，72(4)：288-289.
[18] 柳雪梅，李眷香，崔焕芹，等. 脑膜炎型李斯特菌病一例 [J]. 中国小儿急救医学，2010，3(3)：202.
[19] Ben Shimol S，Einhorn M，Greenberg D. Listeria meningitis and ventriculitis in an immunocompetent child：case report and literature review [J]. Infection，2012，40(2)：207-211.
[20] 冀红，王忠波，马路一，等. 儿童产单核细胞李斯特菌脑膜脑炎1例 [J]. 大连医科大学学报，2011，2(2)：99-100.