儿童紫癜性肾炎治疗进展

摘要/Abstract

摘要：

紫癜性肾炎是最常见的儿童继发性肾小球疾病。其临床表现不一，轻者仅表现为镜下血尿、微量蛋白尿，重者可逐渐进展为肾功能不全，直至终末期肾脏病而需要依靠长期肾脏替代治疗，严重影响患儿生存质量。近年来过敏性紫癜发生率不断提高，需予以重视。关于紫癜性肾炎的治疗，目前国内外有较多的研究，但结果不尽一致，因此至今未有定论。我们提倡阶梯式疗法，即根据患儿临床表现、肾脏病理选择合适的方案，而对于重症紫癜性肾炎，我们推荐多药强化治疗并联合血浆置换等方法以缓解病情。

Abstract: Henoch-Sch?nlein purpura nephritis (HSPN) is the most common secondary glomerular disease in children. The clinical manifestations of HSPN vary from microscopic hematuria, microalbuminuria to renal dysfunction even end stage renal disease which is needed to rely on long-term renal replacement therapy, thus affecting the quality of children life seriously. In recent years, the incidence of Henoch-Sch?nlein purpura continues to increase, which should be paid more attention. There are many studies about the treatment of HSPN both at home and abroad, yet no certain conclusion is drawn because of the inconsistent results. We advocate stepped therapies, that is, the appropriate regimens are chosen based on the clinical manifestations and renal pathology in children. For severe HSPN, we recommend multi-drug intensive therapy combined with other methods such as plasma exchange to alleviate the symptoms.

叶乐珍，周江瑾综述. 儿童紫癜性肾炎治疗进展[J]. 临床儿科杂志, 2014, 32(4): 392-395.

Reviewer:YE Lezhen,ZHOU Jiangjin . Progress in treatment of pediatric Henoch-Sch?nlein purpura nephritis　[J]. , 2014, 32(4): 392-395.

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