人白细胞抗原B*1502 基因型和年龄对抽搐或癫痫患儿血同型半胱氨酸浓度的影响

doi:10.3969/j.issn.1000-3606.2017.03.008

临床儿科杂志 ›› 2017, Vol. 35 ›› Issue (3): 187-.doi: 10.3969/j.issn.1000-3606.2017.03.008

人白细胞抗原B*1502 基因型和年龄对抽搐或癫痫患儿血同型半胱氨酸浓度的影响

张春^1_,　何大可^2_,　黄晓会^1_,　魏昕^1_,　马婧^1_,　祁佳^1_,　刘艳^1_,　徐阿晶^1_,　卜书红¹

上海交通大学医学院附属新华医院1 . 药学部，2 . 儿神经内科（上海　200092）

收稿日期:2017-03-15 出版日期:2017-03-15 发布日期:2017-03-15
通讯作者: 卜书红 E-mail:sophia5237@126 .com
基金资助:
上海交通大学医学院基金 (No. 14XJ10033)

Effect of human leukocyte antigen B*1502 genotype and age on serum homocysteine levels in children with seizures or epilepsy

ZHANG Chun¹, HE Dake², HUANG Xiaohui¹, WEI Xin¹, MA Jing¹, QI Jia¹, LIU Yan¹, XU Ajing¹, BO Shuhong¹

1.Department of Pharmacy, 2. Department of Pediatric Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

Received:2017-03-15 Online:2017-03-15 Published:2017-03-15

摘要/Abstract

摘要： 　目的　探讨具有人白细胞抗原B*1502(HLA-B*15:02)不同基因型和年龄对抽搐或癫痫患儿血浆同型半胱氨酸(Hcy )浓度的影响，研究患儿血浆Hcy浓度的影响因素，以减少血浆Hcy增高所致的潜在致病风险。方法　选取2015 年10月至2016年6月间检测HLA-B*15:02基因型的抽搐或癫痫患儿15例，比较不同基因型患儿的血浆Hcy浓度；并将后者对应患儿年龄作线性回归分析。结果　血浆Hcy平均浓度在未携带HLA-B*15:02基因患儿中为(8.38±4.23)μmol/L，在携带HLA-B*15:02基因患儿中为(13.03±0.97)μmol/L，携带者明显高于未携带者。随着患儿年龄增加，血浆Hcy浓度有增高趋势 (r2=0.29, P＜0.05 )。结论　HLA-B*15:02基因携带者和较大年龄抽搐或癫痫患儿有发生血Hcy增高的倾向，增加患儿潜在致病风险。HLA-B*15:02基因型和年龄可预测抽搐患儿血浆Hcy浓度变化倾向。

Abstract: 　Objective　To explore the effect of human leukocyte antigen B* genotype and age on serum homocysteine (Hcy) levels in children with seizures or epilepsy. Methods　Fifteen children with seizures or epilepsy in whom HLA-B*15:02 genotype was detected during October 2015 to June 2016 were included. The plasma Hcy concentration in children with different genotypes was compared. The association of Hcy concentration and age was performed by linear-regression analysis. Results　The mean concentration of Hcy was 8.38±4.23 μmol/L in children not carrying HLA-B*15:02 gene, which was obviously higher than that in children carrying HLA-B*15:02 gene 13.03±0.97 μmol/L (P<0.05). The Hcy concentration increased with the age (r2 =0.29, P<0.05). Conclusions　Elder children with seizures or epilepsy carrying HLA-B*15:02 gene tend to have higher Hcy concentration and increased potential risk of disease. HLA-B*15:02 gene type and age can predict the changes of Hcy concentration in children with convulsions.

张春,　何大可,　黄晓会,　魏昕,　马婧,　祁佳,　刘艳,　徐阿晶,　卜书红. 人白细胞抗原B*1502 基因型和年龄对抽搐或癫痫患儿血同型半胱氨酸浓度的影响[J]. 临床儿科杂志, 2017, 35(3): 187-.

ZHANG Chun, HE Dake, HUANG Xiaohui, WEI Xin, MA Jing, QI Jia, LIU Yan, XU Ajing, BO Shuhong. Effect of human leukocyte antigen B*1502 genotype and age on serum homocysteine levels in children with seizures or epilepsy[J]. , 2017, 35(3): 187-.

人白细胞抗原B*1502 基因型和年龄对抽搐或癫痫患儿血同型半胱氨酸浓度的影响

Effect of human leukocyte antigen B*1502 genotype and age on serum homocysteine levels in children with seizures or epilepsy

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