›› 2014, Vol. 32 ›› Issue (6): 536-539.

• Original Article • Previous Articles     Next Articles

The expression of JC virus T-antigen in colorectal juvenile polyps in children

ZHANG Lina, PAN Jian, JIN Yu   

  1. (Department of Gastroenterology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, Jiangsu, China)
  • Received:2013-12-12 Online:2014-06-15 Published:2014-06-15

Abstract:  Objective To investigate the relationship between Jamestown Canyon virus (JCV) infection and colorectal juvenile polyps in children. Methods PCR and immunohistochemical staining were performed to detect JCV DNA sequences and localize T-Ag expression in 35 colorectal juvenile polyps and 23 normal colorectal mucosa. Results The positive rate of JCV gene sequences was 31.4% (11 of 35) in the colorectal juvenile polyps and 8.7% (2 of 23) in the normal colorectal mucosa (P<0.05). T-Ag protein was expressed in 22.9% (8 of 35) of the colorectal juvenile polyps, but none in the normal colorectal mucosa (P<0.05). Gender, age, and the number, location, and size of the colorectal juvenile polyps were not significantly different between the children with JCV-positive and JCV-negative polyps (P>0.05). Conclusions This study suggests a positive association between JCV infection and colorectal juvenile polyps in children, indicating that JCV infection may be a risk factor for colorectal juvenile po-lyps in children.