儿童高尿酸血症血清IL-1β、IL-6 水平及其临床意义

doi:10.3969/j.issn.1000-3606.2017.08.008

临床儿科杂志 ›› 2017, Vol. 35 ›› Issue (8): 592-.doi: 10.3969/j.issn.1000-3606.2017.08.008

儿童高尿酸血症血清IL-1β、IL-6 水平及其临床意义

陈圆玲¹,　王佳佩²,　孙楠³,　戴霞华¹,　狄亚珍¹,　沈梦娇²,　应倩倩²

1.宁波市妇女儿童医院小儿风湿免疫科（浙江宁波　315000）；2.宁波大学医学院（浙江宁波　315000）；3 . 天津市儿童医院小儿免疫科（天津　300074）

收稿日期:2017-08-15 出版日期:2017-08-15 发布日期:2017-08-15
通讯作者: 狄亚珍 E-mail:dyz028sci@163 .com
基金资助:
浙江省医药卫生平台研究计划（No. 2015 ZDA 027）；宁波市自然基金项目（No. 2014A610280）

Clinical significance of serum interleukin-1β and interleukin-6 levels in childhood hyperuricemia

CHEN Yuanling¹, WANG Jiapei², SUN Nan³, DAI Xiahua¹, DI Yazhen¹, SHEN Mengjiao², YING Qianqian²

1.Department of Pediatric Rheumatology and Immunology, Ningbo Women and Children's Hospital, Ningbo 315000, Zhejiang, China; 2. Medical School, Ningbo University, Ningbo 315000, Zhejiang, China; 3.Department of Pediatric Immunology, Tianjin Children’s Hospital, Tianjin 300074, China

Received:2017-08-15 Online:2017-08-15 Published:2017-08-15

摘要/Abstract

摘要： 　目的　探讨血清白介素-1β（ IL-1β）及白介素-6（IL-6）在儿童高尿酸血症（HUA）发病中的作用及意义。方法　选择HUA患儿71例，按是否有关节红肿热痛及活动障碍病史分为有关节症状组（GA组， n=28）及无关节症状组（NGA组， n=43）；同时选取71例健康体检儿童和腹股沟斜疝修补术患儿为对照组。采用双抗体夹心酶联免疫吸附法（ELISA）检测所有患儿血清IL-1β、IL-6水平。结果　HUA组患儿血清IL-1β、IL-6浓度高于正常对照组，差异均有统计学意义（P均<0.05）；GA组急性期血清IL-1β、IL-6浓度高于缓解期、NGA组及正常对照组，GA组缓解期和NGA组血清IL-1β、IL-6浓度高于正常对照组，差异均有统计学意义（P均<0.05）。患儿血清IL-1β、IL-6浓度与血白细胞计数、中性粒细胞、单核细胞、血尿酸、血沉、 C反应蛋白、尿素氮、肌酐水平呈显著正相关（P均<0.05） )，与血三酰甘油、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平无相关性（P均>0.05）。结论　IL-1β、IL-6在HUA患儿的炎症反应机制中发挥重要作用。

Abstract: 　Objective　To explore the significance of interleukin (IL)-1β and IL-6 in serum of children with hyperuricemia (HUA). Methods　142 children including 71 children with HUA (HUA group) and 71 control children (control group), healthy and inguinal hernia children were selected as control group. 71 HUA children were subdivided into GA (gout attacks) group (n=28) and NGA (non-gout attacks) group (n=43) according to whether they had a history of acute gout attacks, including sudden monoarthritis of rapid onset with intense pain and swelling or without. Enzyme-linked immunosorbent assay was used to measure the level of IL-1β and IL-6 in serum. Results Serum IL-1β and IL-6 levels of HUA children were significantly higher than those of control group (all P<0.05). Serum IL-1β and IL-6 levels of HUA children in GA group were significantly higher than those of NGA group (P<0.05). Serum IL-1β and IL-6 levels of GA group in acute phase was significantly higher than those of HUA children in remission stage、NGA group and control group (P<0.05). Serum IL-1β and IL-6 levels of GA group in remission stage and NGA group was significantly higher than those of control group (P<0.05). There were no significant differences between HUA children in remission stage and NGA group (P>0.05). The serum IL-1β and IL-6 levels of HUA children were positively correlated with WBC, neutrophils, monocytes, uric acid, ESR, CRP, BUN and Cr (all P<0.05), while not correlated with triglyceride, total cholesterol, LDL-C and HDL-C(all P<0.05). Conclusion IL-1β and IL-6 play an important role in the pathogenesis of HUA in children.

陈圆玲,　王佳佩,　孙楠,　戴霞华,　狄亚珍,　沈梦娇,　应倩倩. 儿童高尿酸血症血清IL-1β、IL-6 水平及其临床意义[J]. 临床儿科杂志, 2017, 35(8): 592-.

CHEN Yuanling, WANG Jiapei, SUN Nan, DAI Xiahua, DI Yazhen, SHEN Mengjiao, YING Qianqian. Clinical significance of serum interleukin-1β and interleukin-6 levels in childhood hyperuricemia[J]. , 2017, 35(8): 592-.

儿童高尿酸血症血清IL-1β、IL-6 水平及其临床意义

Clinical significance of serum interleukin-1β and interleukin-6 levels in childhood hyperuricemia

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