临床儿科杂志 ›› 2021, Vol. 39 ›› Issue (12): 956-.doi: 10.3969/j.issn.1000-3606.2021.12.018

• 继续医学教育 • 上一篇    

肠道菌群与儿童食物过敏研究进展

江沿,詹学   

  1. 重庆医科大学附属儿童医院消化科 国家儿童健康与疾病临床医学研究中心 儿童发育疾病研究 教育部重点实验室 儿科学重庆市重点实验室(重庆 400014)
  • 发布日期:2021-12-22

Continuing Medical Education Advances in researching the relationship between gut microbiota and food allergy in children

JIANG Yan, ZHAN Xue   

  1. Department of Gastroenterology Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014 , China
  • Published:2021-12-22

摘要: 近年来,全球食物过敏的发病率大幅上升,食物过敏已成为全球性公共卫生问题。多项研究表明,肠道菌群 结构和功能变化与机体食物过敏的发生密切相关;肠道菌群还可通过调节免疫平衡、维持肠黏膜屏障功能促进机体免疫 耐受形成。现阶段,益生菌作为微生态制剂可调节肠道菌群结构,在食物过敏中的应用受到广泛关注。文章阐述肠道菌群 与儿童食物过敏发生之间的关系。

关键词: 肠道菌群; 食物过敏; 儿童

Abstract: Food allergy prevalence has been rising substantially in recent decades, it has became a global public health problem. Multiple studies suggest that changes in the structure and function of the gut microbiota are closely related to the occurrence of food allergy. Gut microbiota can promote the immune tolerance by regulating immune balance and maintaining the intestinal mucosal barrier function. Now, probiotics, as microecological agents, which can regulate the structure of gut microbiota has received extensive concerns for the application in food allergy. The article reviews the relationship between gut microbiota and food allergy in children, in order to provide new strategies for the prevention and treatment of food allergy in children.

Key words: gut microbiota; food allergy; child