临床儿科杂志 ›› 2015, Vol. 33 ›› Issue (3): 238-.doi: 10.3969j.issn.1000-3606.2015.03.010

• 综合报道 • 上一篇    下一篇

儿童甲状腺癌与自身免疫性甲状腺疾病相关性研究

张玲,李树红,张静,许国春   

  1. 湖北民族学院附属民大医院(湖北恩施 445000)
  • 收稿日期:2015-03-15 出版日期:2015-03-15 发布日期:2015-03-15
  • 通讯作者: 张玲 E-mail:zhanglinghin@126.com

Relationship between autoimmune thyroid disorders and thyroid cancer in children

ZHANG Ling1, LI Shuhong1, ZHANG Jing1,  XU Guochun   

  1. Affiliated Hospital of Hubei Institute for Nationalities, Enshi 445000, Hubei, China
  • Received:2015-03-15 Online:2015-03-15 Published:2015-03-15

摘要: 目的 探讨儿童甲状腺癌与自身免疫性甲状腺疾病之间的关系。方法 回顾性分析2000年至2008年行甲状腺切除术并经病理确诊为甲状腺癌的68例患儿的临床资料,比较伴发与不伴发自身免疫性甲状腺疾病的甲状腺癌患儿的年龄、性别、结节大小、淋巴结转移、侵袭状态等临床及病理特征。结果 68例甲状腺癌患儿中,31例(45.6%)伴发自身免疫性甲状腺疾病;与37例未伴发自身免疫性甲状腺疾病的患儿相比,伴发自身免疫性甲状腺疾病患儿中女性比例更高、年龄更大、结节直径更小、促甲状腺激素水平和甲状腺球蛋白水平更高、生存时间更短,无病生存比例低、复发率高,差异均有统计学意义(P<0.05)。结论 儿童自身免疫性甲状腺疾病与甲状腺癌的关系密切,对自身免疫性甲状腺疾病患儿应加强随访。

Abstract: Objective To investigate the relationship between autoimmune thyroid disorders (AITD) and thyroid cancer (TC) in children. Methods  Clinical date from 68 patients who underwent thyroidectomy and were histologically confirmed with TC were retrospectively analyzed from 2000 to 2008. Age, gender, nodular size, lymph node metastasis, and invasive status of thyroid cancer were compared between patients with and without AITD. Results  In 68 patients with TC, 45.6% (31/68) patients had concurrent AITD. Compared with those without AITD, a greater female preponderance, older age, smaller tumour size, higher TSH values, higher TG  values, shorter survival time, lower disease free survival rate, and higher relapse rate were found in patients with AITD (P<0.05). Conclusions  AITD are associated with TC in children. Follow-up is suggested in children with AITD.