临床儿科杂志 ›› 2015, Vol. 33 ›› Issue (3): 265-.doi: 10.3969j.issn.1000-3606.2015.03.017

• 综合报道 • 上一篇    下一篇

38例儿童颞叶难治性癫痫病理分析#br#

王江娅1,李文玲2,武江2,赵焕芬3,毛金丽1,娄燕1   

  1. 河北省人民医院1.儿科,2.功能神经外科,3.病理科(河北石家庄 050051)
  • 收稿日期:2015-03-15 出版日期:2015-03-15 发布日期:2015-03-15
  • 通讯作者: 娄燕 E-mail:13231195903@163.com

Neuropathological findings in 38 children with temporal lobe intractable epilepsy

WANG Jiangya1, LI Wenling2, Wu Jiang2, Zhao Huanfen3, Mao Jinli1, LOU Yan1   

  1. 1. Department of Pediatrics, 2. Department of Functional Neurosurgery,  3.Department of Pathology, Hebei General Hospital, Shijiazhuang 050051, Hebei, China
  • Received:2015-03-15 Online:2015-03-15 Published:2015-03-15

摘要: 目的 探讨儿童颞叶难治性癫痫的病理特征。方法 回顾性分析2011年10月至2013年10月行手术治疗的38例颞叶癫痫患儿的病理资料。结果 38例患儿年龄2.5~14岁,男21例、女17例。病理诊断局灶性皮层发育不良(FCD)21例,其中FCDⅠa 1例、FCDⅠb 2例、FCDⅡa 2例、FCDⅡb 3例、FCDⅢa 5例、FCDⅢb 1例、FCDⅢc 1例、FCDⅢd 6例;微皮层发育不良3例;单纯海马硬化3例;神经系统肿瘤7例,其中胚胎发育不良性神经上皮瘤5例,星形胶质瘤2例;脑炎2例;蛛网膜囊肿2例。结论 FCD是引起儿童颞叶难治性癫痫最常见的原因,其中FCDIIId型为最常见的亚型。

Abstract: Objectives To explore the neuropathological characteristics of children with temporal intractable epilepsy. Methods A retrospective analysis of the pathological characteristics was conducted in 38 children who underwent epilepsy surgery from December 2011 to December 2013. Results Among 38 patients, aged 2.5-14 years, 21 boys and 17 girls, 21 cases had focal cortical dysplasia (FCD), 1 case had FCDⅠa, 2 cases had FCDⅠb, 1 case had FCDⅡa, 3 cases had FCDⅡb, 5 cases had CDⅢa, 1 case had FCDⅢb, 1 case had FCDⅢc, 6 cases had FCDⅢd. Three cases had microdysgenesis, 3 cases had simple hippocampal sclerosis, 7 cases had neoplasms, 5 cases had dysembryoplastic neuroepithelial tumor, 2 cases had astroglioma, 2 cases had encephalitis, 2 cases had arachnoid cyst. Conclusions FCD is the most common form that causes temporal lobe intractable epilepsy in children. FCDIIId is the most common subtype in FCD.