临床儿科杂志 ›› 2019, Vol. 37 ›› Issue (11): 837-.doi: 10.3969/j.issn.1000-3606.2019.11.010

• 综合报道 • 上一篇    下一篇

自主神经介导性晕厥儿童在直立倾斜试验中阳性反应与并发症的早期发现和处理

黎瑶,何爽,张蕾,刘晓燕   

  1. 重庆医科大学附属儿童医院心血管内科; 儿童发育疾病研究教育部重点实验室; 儿童发育重大疾病 国家国际科技合作基地; 儿科学重庆市重点实验室(重庆 400014)
  • 出版日期:2019-11-15 发布日期:2020-02-03
  • 通讯作者: 刘晓燕 电子信箱:lxylxy65@163.com
  • 基金资助:
    “十二五”国家科技支撑计划 ( No.2012BAI03B03)

Early detection and management of positive reactions and complications of neurally mediatied syncope in children during head-up tilt test

 LI Yao, HE Shuang, ZHANG Lei, LIU Xiaoyan   

  1. Department of Cardiovascular Disease,Children’s Hospital of Chongqing Medical University, Chongqing 400014,China; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China
  • Online:2019-11-15 Published:2020-02-03

摘要: 目的 探讨如何早期发现并及时处理自主神经介导性晕厥(NMS)患儿在直立倾斜试验(HUTT)中的阳性反 应与并发症。方法 回顾分析行HUTT检查阳性确诊NMS患儿的临床资料。结果 201例NMS患儿中,男性95例、女性 106例,年龄7岁4月~16岁9月,血管迷走性晕厥(VVS)103例、体位性心动过速综合征(POTS)98例。患儿在HUTT中, 晕厥再现5例(2.5%),均为VVS;出现并发症200例(99.5%),其中窦性心动过速182例(90.5%)、窦性心动过缓38例 (18.9%),包括心率骤升骤降20例(10.0%),心脏停搏2例(1.0%),交界性逸搏心律2例(1.0%),II度房室传导阻滞1例 (0.5%),房性早搏1例(0.5%),抽搐2例(1.0%),暂时性失语2例(1.0%)。达到阳性反应后迅速将倾斜床恢复至水平位, 晕厥者予以吸氧并抬高及按摩双下肢,心脏停搏者予以胸外心脏按压,部分清醒后予口服牛奶等处理,全部患儿短时间内 临床表现消失,意识、心率、血压、心电图恢复正常,无遗留后遗症及死亡病例。181例(90.0%)患儿在HUTT中有晕厥先兆, 108例(53.7%)先有晕厥先兆其后达到阳性反应标准,其中103例在晕厥先兆出现后的8分钟内达到阳性反应标准;47例 (23.4%)晕厥先兆与到阳性反应几乎同时出现。结论 NMS儿童在HUTT时存在一定风险,早期发现并及时处理阳性反 应和并发症,是降低试验风险的关键。

关键词: 晕厥; 直立倾斜试验; 阳性反应; 并发症; 儿童

Abstract:  Objective To explore early detection and timely treatment of positive reactions and complications of neurally mediated syncope (NMS) children during head-up tilt test (HUTT). Methods Clinical data of children with NMS diagnosed with HUTT positive examination were retrospectively analyzed. Results In 201 NMS patients, there were 95 males and 106 females, aged from 7.33 to 9.75 years old. Of them, 98 cases were postural tachycardia syndrome, and 103 cases were vasovagal syncope (VVS). In HUTT test, 5 (2.5%)cases had syncope who were all VVS, 200 (99.5%)cases have complications including 182 (90.5%) with sinus tachycardia and 38 (18.9% ) with sinus bradycardia. In all cases with sinus tachycardia and sinus bradycardia, there were 20 cases (10.0%) with sudden rise and drop in heart rate, 2 (1.0%) with cardiac arrest, 2 (1.0%) with junctional escape beat, 1(0.5%) with II° atrioventricular block, 1 (0.5%) with atrial prematuem beats, 2 (1.0%) with convulsions, and 2 (1.0%)with temporary aphasia. By lying down immediately, once reached positive reaction, oxygen supply, raising and massaging both lower extremities if syncope occurs, compressing chest if cardiac arrest occurs, partial patients given oral milk after wakefulness, and the manifestations above in all the patients disappeared quickly, consciousness, heart rate, blood pressure, ECG return to normal, and no sequela and death. It showed 90.0% (181/201) presyncope in HUTT, and 53.7%(108/201) had presyncope, after then reached positive response, 95%(103/108) of these patients had reached positive response after presyncope in 8 min. There were 23.4% (47/201)presyncope and positive response occurred simultaneously. Conclusion NMS children have risk during HUTT. The key to reduce the risk of test is to recognize and manage the positive reaction and complications in time.

Key words:  syncope; head-up tilt test; positive reaction; complications; child