川崎病诊断相关生物学标志物的研究现状及进展

doi:10.3969/j.issn.1000-3606.2020.10.017

临床儿科杂志 ›› 2020, Vol. 38 ›› Issue (10): 789-.doi: 10.3969/j.issn.1000-3606.2020.10.017

川崎病诊断相关生物学标志物的研究现状及进展

王亮，司萍

天津市儿童医院检验科（天津 300074）

出版日期:2020-10-15 发布日期:2020-10-10

Status and progress of research in biomarkers for the diagnosis of Kawasaki disease

WANG Liang, SI Ping

Department of Laboratory Medicine, Tianjin Children's Hospital, Tianjing, 300074

Online:2020-10-15 Published:2020-10-10

摘要/Abstract

摘要： 川崎病（KD）是一种以全身性血管炎为主要病理改变的急性发热出疹性疾病，而冠状动脉损伤（CAL）是KD 最严重的并发症。KD具有季节性、区域性、疾病自限性，以及婴幼儿高发性等特点。早期应用静脉注射免疫球蛋白（IVIG）能预防大部分患儿发生CAL，但仍有部分患儿对IVIG无反应，并且CAL发生率更高。因此，KD的早期诊断对于减少CAL 以及提高KD患儿生存质量具有重要意义。近年来，许多研究致力于探索KD相关的生物标记物，其中一些已经被证明可以预测IVIG无反应，而另一些则可能预示CAL发生风险，现综述相关研究现状与进展。

关键词: 川崎病；静脉注射免疫球蛋白；冠状动脉损伤；生物学标志物；诊断

Abstract: Kawasaki?disease?(KD)?is?an?acute?febrile?and?rash?disease?with?systemic?vasculitis?as?the?main?pathological? change.?The?coronary?artery?lesion?(CAL)?is?the?most?serious?complication?of?KD.?KD?has?the?characteristics?of?seasonality,? regionality,?self-limitation?and?high?incidence?in?infants?and?young?children.?Early?administration?of?intravenous?immunoglobulin? (IVIG)?can?prevent?the?occurrence?of?CAL?in?most?children.?However,?some?children?are?still?unresponsive?to?IVIG,?and?the? incidence?of?CAL?is?higher.?Therefore,?early?diagnosis?of?KD?is?of?great?significance?for?reducing?CAL?and?improving?the?life? quality?of?KD?children.?This?paper?reviews?the?current?status?and?progress?of?related?research.

Key words: Kawasaki?disease;? intravenous?immunoglobulin;? coronary?artery?lesion;? biomarker;? diagnosis

王亮，司萍. 川崎病诊断相关生物学标志物的研究现状及进展[J]. 临床儿科杂志, 2020, 38(10): 789-.

WANG Liang, SI Ping. Status and progress of research in biomarkers for the diagnosis of Kawasaki disease[J]. Journal of Clinical Pediatrics, 2020, 38(10): 789-.

川崎病诊断相关生物学标志物的研究现状及进展

Status and progress of research in biomarkers for the diagnosis of Kawasaki disease

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