肠道病毒71 型疫苗研究进展

doi:10.3969/j.issn.1000-3606.2021.05.016

临床儿科杂志 ›› 2021, Vol. 39 ›› Issue (5): 391-.doi: 10.3969/j.issn.1000-3606.2021.05.016

肠道病毒71 型疫苗研究进展

毕方川综述许红梅审校

重庆医科大学附属儿童医院感染科儿童发育疾病研究教育部重点实验室国家儿童健康与疾病临床医学研究中心儿童发育重大疾病国家国际科技合作基地儿科学重庆市重点实验室（重庆 400014）

发布日期:2021-05-07
基金资助:
国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”资助项目（No. 2018 ZX 10713 -002）

Research progress on enterovirus 71 vaccines

Reviewer: BI Fangchuan, Reviser: XU Hongmei

(Department of Infectious Diseases, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorder, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China

Published:2021-05-07

摘要/Abstract

摘要： 手足口病（HFMD）是一种婴幼儿常见的传染性疾病。肠道病毒71型（EV-A 71）是HFMD的主要病原之一，可导致严重并发症甚至造成死亡。因此，预防EV-A71感染尤为必要。开发EV-A71疫苗是预防、控制EV-A71感染最有效的方法。正在研发的EV-A 71疫苗主要包括：灭活全病毒疫苗、减毒活疫苗、病毒样颗粒疫苗、重组VP 1蛋白疫苗和合成多肽疫苗。现就EV-A 71候选疫苗的开发和进展作一综述。

关键词: 手足口病；肠道病毒71型；疫苗

Abstract: Hand, foot and mouth disease (HFMD) is a common infectious disease in infants and young children. Enterovirus 71 (EV-A 71 ) is one of the main pathogens of HFMD, which could cause serious complications and even death. Therefore, it is an urgent need to protect against EV-A 71 infection. Development of EV-A 71 vaccine would be the most effective approach to prevent and control EV-A 71 infection. The EV-A 71 vaccines under development mainly include inactivated vaccines, attenuated live vaccines, virus-like particle vaccines, recombinant epitope vaccines, and synthetic peptide vaccines. This article summarizes the progress and development of the EV-A 71 vaccine.

Key words: hand, foot and mouth disease; enterovirus A 71 ; vaccine

毕方川. 肠道病毒71 型疫苗研究进展[J]. 临床儿科杂志, 2021, 39(5): 391-.

BI Fangchuan. Research progress on enterovirus 71 vaccines[J]. Journal of Clinical Pediatrics, 2021, 39(5): 391-.

肠道病毒71 型疫苗研究进展

Research progress on enterovirus 71 vaccines

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