Toll样受体4和Toll样受体7在儿童原发性肾病综合征患儿肾组织中的表达及意义

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (6): 512-516.

Toll样受体4和Toll样受体7在儿童原发性肾病综合征患儿肾组织中的表达及意义

张芳敏^{1, 2}, 韩子明², 赵德安²

1. 新乡医学院（河南新乡　453003）； 2. 新乡医学院第一附属医院儿科（河南卫辉　453100）

收稿日期:2014-03-08 出版日期:2014-06-15 发布日期:2014-06-15

The expression and clinical significance of toll-like receptor (TLR) 4 and TLR7 on renal tissue in children with primary nephrotic syndrome

ZHANG Fangmin^1，2, HAN Ziming², ZHAO Dean²

(1. Xinxiang Medical University, Xinxiang 453003, Henan, China; 2. Department of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan, China)

Received:2014-03-08 Published:2014-06-15 Online:2014-06-15

摘要/Abstract

摘要：

　目的　探讨Toll样受体（TLR）4、TLR7在儿童原发性肾病综合征（PNS）不同肾脏病理类型中的表达及临床意义。方法　纳入110例确诊且经肾活检的PNS患儿，采用免疫组化方法检测肾组织中的TLR4、TLR7，以21例肾母细胞瘤患儿的正常肾组织为对照，分析比较PNS患儿与对照儿童间以及不同病理分型PNS患儿间，肾组织TLR4、TLR7表达的差异。结果　不同病理类型PNS患儿和对照组之间肾小管中TLR4、TLR7表达的差异均有统计学意义（P<0.01），其中肾小管TLR4表达水平以MCD型最高，其次MN型、MsPGN型、FSGS型，两两比较差异均有统计学意义（P<0.05）；而肾小管TLR7表达水平以MsPGN型最高，其次为MN型、MCD型、FSGS型，两两比较差异也均有统计学意义（P<0.05）。结论　TLR4、TLR7在PNS患儿肾组织中表达增高，且其表达水平可能与病理类型相关。

Abstract: 　Objective　To study the expression and clinical significance of toll-like receptor (TLR) 4 and TLR7 in primary nephrotic syndrome (PNS) of different pathological types in children. Methods Renal expressions of TLR4 and TLR7 were amined and analyzed retrospectively in renal biopsy specimens from 110 PNS patients and 21 healthy controls by immunohistochemical method. According to the renal pathologic classification of PNS, the TLR4 and TLR7 expression levels in PNS of different types were compared. Results Compared with the renal tissue of healthy controls, the expression level of TLR4 on renal tissue of PNS patients was significantly increased (P<0.01). Among MN, MsPGN and FSGS, the highest expression of TLR4 was observed in MCD (P<0.01). Compared with the renal tissue of healthy controls, the expression level of TLR7 in renal tissue of PNS patients was also significantly increased (P<0.01). Among MCD, MN and FSGS, the highest expression of TLR7 was observed in MsPGN (P<0.01). Conclusions TLR4 and TLR7 expression levels are increased in renal tissue of PNS patients and the expression levels may be correlated with renal pathological types.

张芳敏, 韩子明, 赵德安. Toll样受体4和Toll样受体7在儿童原发性肾病综合征患儿肾组织中的表达及意义[J]. 临床儿科杂志, 2014, 32(6): 512-516.

ZHANG Fangmin,HAN Ziming,ZHAO Dean
. The expression and clinical significance of toll-like receptor (TLR) 4 and TLR7 on renal tissue in children with primary nephrotic syndrome [J]. , 2014, 32(6): 512-516.

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