Abstract: Objective To analyze the incidence of complications during and after interventional therapy for common congenital heart disease (CHD) in children. Methods From January 2011 to December 2013, interventional therapy of common congenital heart disease which include ventricular septal defect (VSD), atrial septal defect (ASD), patent ductus arteriosus (PDA) and pulmonary valve stenosis (PS) were performed in 2356 patients. Among them, 159 patients who developed complications during and post to interventional therapy were retrospectively analyzed. Results The overall complication rate was 6.75% (159/2356) (11.40% post VSD occlusion, 7.50% post ASD occlusion, 3.09% post PDA occlusion, 1.63% post percutaneous balloon pulmonary valvuloplasty (PBPV) ).The rate of arrhythmia was 4.41%(102/2356). The severe complication rate was 2.71% (64/2356) (3.62% post VSD occlusion, 2.21% post ASD occlusion, 2.53% post PDA occlusion, 1.63% post PBPV). The intraoperative severe complication rate was 0.51%(12/2356); the early severe complication rate was 1.99% (47/2356); the late severe complication rate was 0.21% (5/2356). Interventional therapy rate was 0.13% (3/2356); cardiovascular surgery rate was 0.64% (15/2356); conservative treatment rate was 1.95%(46/2356). The mortality rate was 0.08% (2/2356). Conclusions The complications and mortality rate of interventional therapy for CHD in children are relatively low, but cannot be ignored. The complication could be reduced by choosing proper indications, following the operational procedures and careful operative follow-up.