Abstract: Objective　To analyze the clinical features and bacterial drug resistance of severe sepsis caused by methicillin-resistant Staphylococcus aureus (MRSA) infections in children. Methods　The clinical data and results of antibiotic susceptibility test in 12 children with severe sepsis caused by MRSA infections from January 2010 to December 2013 were analyzed retrospectively. Results　Among 12 children, there were 5 boys and 7 girls. Their age ranged from 8 days to 11 years, with a median age of 1 year and there were 9 infants. All cases presented with acute onset which included 5 cases of acute osteomyelitis or purulent arthritis, 5 cases of necrotizing pneumonia with pyothorax, one case of necrotizing fasciitis and one case of bloodstream infection. 8 cases were complicated by skin and soft tissue infection, 7 cases by septic shock and 1 case by disseminated intravascular coagulation. The levels of C-reactive protein were increased in all children and white blood cell counts were decreased in 4 children. The susceptibility testing showed MRSA was sensitive to vancomycin and linezolid, and resistant to erythromycin, clindamycin and compound sulfamethoxazole. After treatment with surgical debridement and closed-chest drainage, 8 cases survived and 4 cases died. Conclusions　The severe sepsis caused by MRSA infections was common in infants with sudden onset and rapid progress, so active treatments are needed.