Abstract: 　Objective　To explore the clinical and imaging features of reversible splenial lesion syndrome (RESLES) in children. Methods　The clinical and imaging data of 11 children with RESLES admitted from December. 2011 to May 2015 were retrospectively analyzed. Results　A total of 11 children, 7 males and 4 females with an average age of (6.24±1.41) years (8 months to 11 years old), were found 8 RESLES type-1 and 3 RESLES type-2. The common causes were convulsion and infection. Excep the manifestations of primary diseases, disturbance of consciousness was the prominent clinical manifestations, other neurological manifestations were mild or absent. Cranial magnetic resonance image (MRI) showed that the splenium of corpus callosum with isolated oval lesions in 8 cases with RESLES type-1, and the lesions involved the whole corpus callosum, periventricular and centrum ovale white matter in 3 cases with RESLES type-2. All the lesions showed low or equal signal on T1 weighed images, high signal on T2 weighed images, FLAIR images, and diffusion weighed images, low signal on apparent diffusion coefficient. The original lesions were completely disappeared on the follow-up MRI (interval of 4-30 days). Follow-up of 2 months to 3 years and 6 months, the cranial MRI were normal. Conclusions　The etiology of RESLES in children is complex, no specific clinical manifestations. The diagnosis mainly depends on the cranial MRI, especially the diffusion weighted images, showing the symmetry lesions on splenium of corpus callosum or with bilateral white matter. The prognosis of EESLES is good. Excessive treatment should be avoided.