Abstract: Objective　To analyze the effect and satisfaction of clinical pathway for managing children with Kawasaki disease (KD). Methods　Data were collected from 224 children hospitalized with KD from January 2009 to December 2013. According to the implementation of clinical pathway management, all patients were divided into non-pathway management group (n=94) and pathway management group (n=130). Length of stay, antibiotics usage, total cost of hospitalization, treatment cost, medication cost, examination cost, and laboratory testing cost were compared between the two groups. Satisfaction of clinical pathway management was surveyed. Results　The average lengths of stay and percentages of antibiotics usage between the two groups were of no significant difference (P>0.05). The total cost of hospitalization and laboratory testing cost in clinical pathway group were (9597±2199) yuan and (1904±421) yuan, significant higher than those in non-pathway group [(8014±3330) yuan and (1168±409) yuan]. The therapy cost and medication cost between the two groups were of no significant difference (P>0.05). The questionnaire survey showed that application of clinical pathway did not increase the satisfaction of parents. However, the satisfaction of medical staffs was low because the increased workload, especially the pediatricians. Conclusions　Clinical pathway management has some advantages, but should be further improved in accordance with national conditions and regional situation.