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缺氧缺血性脑病中胰岛素样生长因子 -1 的研究进展

  • 武楠 ,
  •  陈婷
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  • 1.兰州大学第一临床医学院(甘肃兰州 730000); 2. 兰州大学第一医院(甘肃兰州 730000)

收稿日期: 2017-11-15

  网络出版日期: 2017-11-15

Advances in insulin-like growth factor-1 in hypoxic-ischemic encephalopathy

  • WU Nan ,
  • CHEN Ting
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  • 1.The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu, China; 2.The First Affiliated of Lanzhou University, Lanzhou 730000, Gansu, China

Received date: 2017-11-15

  Online published: 2017-11-15

摘要

缺氧缺血性脑病(HIE)是导致新生儿死亡及神经系统后遗症的主要原因。胰岛素样生长因子-1(IGF-1)作 为一种神经营养因子和抗凋亡因子,在中枢神经系统的发育和成熟中起重要的作用。文章综述IGF-1在缺氧缺血性脑损 伤后参与神经保护、神经修复、促进新生血管形成等方面的研究进展。

本文引用格式

武楠 ,  陈婷 . 缺氧缺血性脑病中胰岛素样生长因子 -1 的研究进展[J]. 临床儿科杂志, 2017 , 35(11) : 868 . DOI: 10.3969/j.issn.1000-3606.2017.11.017

Abstract

 Hypoxic-ischemic encephalopathy (HIE) is a common cause of neonatal mortality and neurological sequelae. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor and anti-apoptotic factor that plays an important role in the development and maturation of the central nervous system. In this paper, we intended to provide a new idea and recent progress of HIE by illustrating the mechanism of action of IGF-1 in neuroprotection, nerve repair and neovascularization after brain hypoxia-ischemia injury.
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