缺氧缺血性脑病（HIE）是导致新生儿死亡及神经系统后遗症的主要原因。胰岛素样生长因子-1（IGF-1）作 为一种神经营养因子和抗凋亡因子，在中枢神经系统的发育和成熟中起重要的作用。文章综述IGF-1在缺氧缺血性脑损 伤后参与神经保护、神经修复、促进新生血管形成等方面的研究进展。

　Hypoxic-ischemic encephalopathy (HIE) is a common cause of neonatal mortality and neurological sequelae. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor and anti-apoptotic factor that plays an important role in the development and maturation of the central nervous system. In this paper, we intended to provide a new idea and recent progress of HIE by illustrating the mechanism of action of IGF-1 in neuroprotection, nerve repair and neovascularization after brain hypoxia-ischemia injury.