目的　分析新生儿手足口病的临床特点、治疗及预后。方法　回顾分析2014年7月—2016年5月间收治的 8例新生儿手足口病患儿的临床资料，所有患儿均采用实时荧光定量PCR法进行咽拭子肠道病毒通用型核酸、EV71和 CA16核酸检测。结果　8例新生儿手足口病，男6例、女2例，日龄7~26天； 7例有接触史；临床表现为出疹（8例）、发热 （6例）、烦躁（4例）、呕吐（1例），无惊厥、抽搐。RT-PCR检测肠道病毒显示均为非EV71、非CA16的其他肠道病毒感染。 5 例合并肺部感染，给予抗生素治疗。 8例均预后良好。 结论　新生儿手足口病多有接触史，临床表现无特异性，以非EV71、 非CA16肠道病毒为主，易合并肺部感染。

　Objective　To study the clinical features, treatment and prognosis of neonatal hand-foot-mouth disease. Methods　Neonatal hand-foot-mouth disease patients admitted from July 2014 to May 2016 were retrospectively studied. EV71, CA16 and universal enterovirus were detected from newborn swabs by RT-PCR. Results　A total of 8 neonatal patients with hand-foot-mouth diseases, 6 boys and 2 girls were diagnosed at an age ranged from 7-26 days. Of them, 7 patients had exposure history. Clinical manifestations including rash (8 cases), fever (6 cases), irritability (4 cases) and vomiting (1 case), nobody suffered convulsions. The results of RT-PCR showed pathogen enterovirus not- EV71 and not-CA16. There were 5 cases of pulmonary infection treated with antibiotic therapy. All of the 8 cases had a good prognosis. Conclusions　Most of the handfoot-mouth diseases had exposure history without specific clinical manifestations. They had not- EV71 and not-CA16 intestinal virus infection, some patients had pulmonary infection. Therefore, neonatal hand-foot-mouth diseases need more clinical attention.