目的　探讨Gianotti-Crosti综合征的临床特征。方法　回顾分析55例Gianotti-Crosti综合征患儿的临床资料， 并复习相关文献。结果　55例Gianotti-Crosti综合征患儿中，男性39例、女性16例，平均年龄（2.0±0.5）岁。发病因素中 EB病毒感染最常见，其次是单纯疱疹病毒，未发现乙肝病毒感染。皮损均表现为四肢伸侧、面颊和臀部对称分布的红斑丘 疹。治疗采用抗病毒、抗炎、抗过敏和外用药物，治疗2周后均有效，痊愈率74.5%。结论　Gianotti-Crosti综合征最主要发 病因素是病毒感染，皮损具有特征性，预后好。

Objective　To explore the clinical characteristics of Gianotti-Crosti syndrome. Method　The clinical data of Gianotti-Crosti syndrome in 55 children were retrospectively analyzed, and the relevant literature was reviewed. Results　In 55 children (39 boys and 16 girls) diagnosed with Gianotti-Crosti syndrome, an average age was (2.0±0.5) years. EB virus was the most common pathogen, followed by herpes simplex virus, and no hepatitis B virus infection was found. Skin lesions were characterized by symmetrical distribution of erythematous papules on the extensor side of extremities, cheek, and buttocks. All of them received the treatment of antiviral, anti-inflammatory, anti-allergic and topical medication,  and it was effective after 2 weeks of the treatments. The cure rate was 74.5%. Conclusion　The most important onset factor of Gianotti-Crosti syndrome is virus infection, and skin lesion is characterized and the prognosis is good.