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儿童急性 T 淋巴细胞白血病研究进展#br#

  • 万媛媛
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  • 北京大学国际医院儿童血液科(北京 102206)

收稿日期: 2018-07-15

  网络出版日期: 2018-07-15

Progress in research of acute T lymphoblastic leukemia in children

  • WAN Yuanyuan
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  • Department of Hematology in Children, Peking University International Hospital, Beijing 102206, China

Received date: 2018-07-15

  Online published: 2018-07-15

摘要

儿童急性T淋巴细胞白血病(T-ALL)预后较急性B淋巴细胞白血病(B-ALL)差,比B-ALL更易诱导化疗失败、 更易早期复发、复发后难以再次缓解。近年来,T-ALL患儿预后有所改善,国外报道的5年无事件生存率能达到85%,但大 部分仍停留于60%左右。文章综述儿童T-ALL免疫学、分子生物学及细胞遗传学特点及其治疗、预后的研究进展。

本文引用格式

万媛媛 . 儿童急性 T 淋巴细胞白血病研究进展#br#[J]. 临床儿科杂志, 2018 , 36(7) : 557 . DOI: 10.3969/j.issn.1000-3606.2018.07.020

Abstract

 Compared with acute B lymphoblastic leukemia (B-ALL) in children, the prognosis of T-ALL in children is poorer. It is easier to induce chemotherapy failure and recur early than B-ALL.If recur,T-ALL is difficult to relieve again. In recent years, the prognosis of children with T-ALL has improved.The 5-year event-free survival rate (EFS) reported by some foreign research centers can reach 85%.But most of the research centers remain at around 60%. Understanding the progress of T-ALL is particularly important for the diagnosis and treatment of the disease.The article reviews the progress of T-ALL treatment and prognosis in children,and also reviews the characteristics of T-ALL immunology, molecular biology and cytogenetics.
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