目的　探讨儿童肝母细胞瘤的临床病理特征。方法  回顾分析经病理检查证实的68例肝母细胞瘤患儿的临 床病理资料。结果　68例肝母细胞瘤患儿中男44例、女24例，<3岁55例、≥3岁13例，初发时单发59例，甲胎蛋白（AFP） 均明显升高。高危患儿27例，出现转移和/或肝外临近器官侵袭和/或门静脉及肝静脉三分支/下腔静脉受侵22例。术前 影像分期PRETEXT Ⅳ期患儿13例。患儿年龄、AFP浓度、病理类型和PRETEXT分期有显著相关性（P均<0.05）；病理 学类型和AFP浓度有显著相关性（P=0.002）。 病理学类型在高危组、标危组之间的分布差异有统计学意义（P=0.043）。 结论　儿童肝母细胞瘤患儿临床病理特征差异性可能有助有指导临床治疗和预后评估。

Objective　To explore  the differences of the clinicopathological characteristics of children with hepatoblastoma (HB). Methods　Clinical data of 68 patients with HB confirmed by surgery and pathology in Xinhua Hospital were retrospectively analyzed. Results　In the 68 children (44 males and 24 females) with HB, 55 cases were under 3 years of age, and 13 cases older than 3 years. The patients presented with elevated AFP level and unifocal lesions when diagnosed. 27 patients were classified into high risk group according to SIOPEL, and 13 patients were in PRETEXT Ⅳ stage according to imaging results before operation. There are 22 children with metastases and/or extrahepatic abdominal diseases and/or involvement of the main portal vein or of all three hepatic veins and/or the IVC. There was an obvious relationship between PRETEXT staging and the age, the level of AFP and the pathological classification. (P<0.05). There was an obvious relationship between the pathological classification and the level of AFP (P=0.002).  The pathological classification showed association with AFP level (P=0.002). There was also an obvious relationship between the pathological classification and the risk classification (P=0.043). Conclusions　The difference of clinicopathological features in children with hepatoblastoma may help to guide clinical treatment and prognostic evaluation.