目的　分析伴有面部皮疹的不典型手足口病的临床特征及病原。方法　回顾分析2016年1月至12月手足口 病患儿的临床资料，以及部分患儿的病原学检测结果；按有无面部皮疹，将患儿分为两组进行比较。结果　共纳入11 430 例手足口病患儿，其中伴有面部皮疹的不典型手足口病患儿1 134例，占9.92%。伴面部皮疹的不典型手足口病以<1岁及 ≥3岁儿童多见，临床症状较轻，发热及神经系统并发症发生率均低于无面部皮疹组；病原以柯萨奇病毒A6为主，其比例 明显高于无面部皮疹者；差异均有统计学意义（P<0.05）。 结论　伴有面部皮疹的不典型手足口病以柯萨奇病毒A6感染 为主，临床症状轻且不典型。

Objective　We aimed to compare the clinical and etiological features of hand, foot, and mouth disease (HFMD) with or without facial rash. Methods　Clinical data of children with HFMD reported from January to December 2016 and pathogen test results of some children were retrospectively analyzed. The children were divided into two groups based on whether it is combined with facial rashes or not. Results　A total of 1134 cases of atypical HFMD with facial rash were enrolled, accounting for 9.92% of all HFMD cases (1134/11430), which easily occurring among children under one year of age and over 3 years old. The clinical symptoms of cases with facial rash were milder than those without facial rash, and the incidence of fever and nervous system complications were lower. Coxsackievirus A6 infection was predominant, and the ratio was significantly higher than that without facial rash (P<0.05). Conclusions　The majority of HFMD with facial rashes was caused by Coxsackie virus A6 infection and its clinical symptoms were mild and atypical.