新生儿急性肾损伤（AKI）易发生于早产儿和极低出生体质量儿，其发生率在新生儿重症监护病房（NICU）逐 年升高。由于缺乏有效的防治措施，新生儿AKI的死亡率居高不下，预后极差。连续肾脏替代治疗技术是当前应用于治疗 新生儿AKI的理想方法。目前国内外在新生儿中开展连续肾脏替代治疗已达30余年，虽然已累积一定的临床经验，但仍 存在大量问题。文章综述新生儿连续肾脏替代治疗的现状和精准化发展。

　Neonatal acute kidney injury (AKI) is more likely developed in preterm and very low birth weight infants. The incidence of AKI is increasing year by year in the neonatal intensive care unit. Due to the lack of effective prevention and control measures, the mortality rate is extremely high and the prognosis is very poor. Continuous renal replacement therapy (CRRT) is currently the ideal method for the treatment of neonatal AKI. At present, CRRT technology has been used in newborns both at home and abroad for more than 30 years. Although considerable treatment experience has been accumulated, a large number of problems remain to be solved. This article reviews the present state and precision management of CRRT in neonates.