局灶节段性肾小球硬化（FSGS）是一种临床病理综合征，病理以局灶节段分布的肾小球硬化及足细胞的足突 融合为特征；临床主要表现为大量蛋白尿和肾病综合征；多表现为激素耐药，且常进展成终末期肾病；是儿童时期进展为 终末期肾病的主要疾病之一。近年来全球报道FSGS肾活检检出率呈增多趋势，文章综述FSGS的流行病学进展。

Focal segmental glomerulosclerosis (FSGS) is a clinicopathological syndrome characterized by focal segmental glomerulosclerosis and podocyte fusion. The main clinical manifestations are massive proteinuria and nephrotic syndrome (NS). It mostly is hormone resistant and often progresses to end-stage renal disease. It is one of the main diseases that progress to endstage nephropathy in children. In recent years, the detection rate of FSGS by renal biopsy is increasing worldwide. This article reviews the progress in epidemiology of FSGS.