特应性皮炎（AD）是慢性易复发高度瘙痒的皮肤炎症性疾病，其发病机制复杂，包括遗传易感性、环境因素、 免疫功能改变和皮肤屏障功能障碍等，其中免疫功能异常是AD发病的关键环节。 T淋巴细胞可通过分泌特征性的细胞因 子发挥免疫调节作用，不同的T辅助细胞（Th）亚群，如Th2、Th9、Th17和Th22细胞，表达高水平的IL-31、IL-9、IL-10、 IL-17、IL-22等。文章综述不同T淋巴细胞亚群及其产生的细胞因子对AD发病的影响。

　Atopic Dermatitis (AD) is a highly recurrent and itchy chronic inflammatory disease with a complicated pathogenesis involving genetic susceptibility, environmental factors, immune function deregulations and skin barrier dysfunction. Immunology abnormalities play a significant role in the pathogenesis of AD. T lymphocytes exert immunomodulatory effects by secreting characteristic cytokines. Different T helper cell (Th) subpopulations, such as Th2, Th9, Th17 and Th22 cells, express high levels of IL-31, IL-9, IL-10, IL-17, IL- 22 and so on. The article specifically reviews on the significant effects of different T lymphocyte subsets and the cytokines produced on the pathogenesis of AD.