目的　总结以顽固性腹泻为主要症状的儿童神经母细胞瘤（NB）的临床特点。方法　回顾分析2例以顽固性 腹泻为主要症状的神经母细胞瘤患儿的临床资料，并进行文献复习。结果　2例患儿均为女性、 1岁余，均有顽固性腹泻及 低钾血症。例2为经术后病理确诊的神经母细胞瘤，在化疗过程中出现反复腹泻；例1以腹泻发病，且为最明显症状，伴电 解质紊乱、腹胀、体质量减轻等，腹部可触及包块，经影像学及病理检查确诊为神经母细胞瘤。 2例患儿均为节细胞型神经 母细胞瘤，手术联合化疗后症状缓解，现均无病生存。结论　以顽固性腹泻为主要症状的神经母细胞瘤比较罕见，目前尚 无标准诊断及治疗方案，经过手术及化疗联合治疗效果较好。

　Objective　To summarize the clinical characteristics of neuroblastoma (NB) with refractory diarrhea as the main symptom in children. Method　The clinical data of neuroblastoma with refractory diarrhea as the main symptoms in 2 children were retrospectively analyzed and the literature was reviewed. Results　Both cases of neuroblastoma were female and over one year old and suffered from refractory diarrhea and hypokalemia. In case 1 neuroblastoma was confirmed by postoperative pathology and recurrent diarrhea occurred during chemotherapy. In case 2 onset symptom was diarrhea which was also most obvious symptom. She had electrolyte disturbance, abdominal distension and weight loss. Palpable abdominal mass was observed in the child. Neuroblastoma was diagnosed by imaging and pathological examination. Both cases were ganglion cell type NB, and their symptoms were relieved after surgery combined with chemotherapy. Both survived disease free. Conclusion　Neuroblastoma with refractory diarrhea as the main symptom is rare. There is no standard diagnosis and treatment. The combination of surgery and chemotherapy is effective.