目的　探讨高原地区健康足月新生儿在出生后1~30分钟内血氧饱和度（SpO2）及心率（HR）的变化情况。方 法　采用脉氧饱和度仪持续测定不同海拔地区194例正常足月新生儿在生后1~30分钟的SpO2及HR，描绘生后1~30分 钟的SpO2及HR的P5~P95图表，并比较不同分娩方式、性别及不同海拔地区新生儿的差异。结果　生后1分钟，新生儿平 均SpO2为（59±4）%，平均HR为（135±13）次/min，之后SpO2逐渐上升， 5分钟时达80%，10分钟时上升至89%，15分 钟后稳定在95%左右。HR在生后2分钟后稳定在175次/min左右。出生1~15分钟，不同海拔地区新生儿的SpO2差异均 有统计学意义（P<0.001）；随海拔升高SpO2降低，这种差异在生后20分钟及以后消失。生后1~30分钟，不同海拔地区 新生儿的HR差异均有统计学意义（P<0.001），海拔越高HR越高。不同分娩方式新生儿出生1~30分钟SpO2和HR随时 间变化的趋势有所不同（F=2.45、2.09， P均<0.05），但不同性别之间SpO2和HR随时间变化的趋势类似（P>0.05）。 结 论　随着海拔增高，新生儿出生后1~10分钟的SpO2可略低于窒息复苏指南推荐的SpO2，且上升至90%所需时间延长； 海拔越高，新生儿HR越高。在高原地区进行窒息复苏时应结合临床表现，谨慎用氧，避免高氧损害。

Objective　To explore the changes of blood oxygen saturation (SpO2) and heart rate (HR) in healthy full-term neonates in plateau area within 1 to 30 minutes after birth. Method　The SpO2 and HR of 194 normal full-term newborns at different altitudes were continuously measured by pulse oximeter 1~30 minutes after birth, and the 5th ~ 95th percentile charts of SpO2 and HR at 1~30 minutes after birth were drawn. The differences were compared among different delivery modes, sexes and altitudes in newborns. Results　One minute after birth, the average SpO2 and HR of newborns were 59%±4% and 135±13 times/min. Then SpO2 gradually increased, reaching 80% at 5 minutes, 89% at 10 minutes and stabilizing at about 95% at 15 minutes. HR stabilized at about 175 times/min 2 minutes after birth. The SpO2 differences of newborns at different altitudes were statistically significant from 1 to 15 minutes after birth (P< 0.001). With the increase of altitude, SpO2 of newborns decreased, and the difference disappeared after 20 minutes. The HR of newborns at different altitudes had significant difference from 1 to 30 minutes after birth (P<0.001), and the the HR increased over the altitude. The trend of SpO2 and HR changes over time from 1 to 30 minutes after birth was different in different delivery modes (F=2.45, 2.09, P< 0.05), but they were similar between different genders (P>0.05). Conclusion　As the altitude increases, the SpO2 from 1 to 10 minutes after birth could be slightly lower than the SpO2 recommended by the asphyxia resuscitation guide, and and it takes longer to rise to 90%. The neonatal HR was lower at the higher altitude. In the plateau area, the performance of asphyxia recovery should be combined with the clinical manifestations, and oxygen should be used cautiously to avoid high oxygen damage.