目的　探讨儿童特应性皮炎（AD）疾病严重程度与维生素D水平的相关性。方法　纳入152例AD患儿，以 AD严重程度评分（SCORAD）评估AD严重度，液相色谱-串联质谱法检测血清25-羟维生素D[25(OH)D]，分析AD严重 程度与血清25(OH)D水平的相关性。结果　152例AD患儿中，男81例、女71例，中位年龄3.5岁。轻度、中度、重度AD 患儿分别为 51例（33.6%）、80例（52.6%）、19 例（12.5%）。 血清25(OH)D充足55 例（36.2%），不足65 例（42.8%），缺 乏32 例（21.1%）。AD患儿SCORAD评分与血清25(OH)D水平无显著相关性（r=－0.047， P=0.567），与血清总IgE呈显 著正相关（r=0.244， P=0.003），与血嗜酸性粒细胞比例呈显著正相关（r=0.239， P=0.004）。 结论　AD儿童中血清维生 素D缺乏和不足者较多，但AD的严重程度与血清25(OH)D水平无显著相关性。

Objective To study the correlation of serum vitamin D [25(OH)D] levels with the severity of childhood atopic dermatitis (AD). Methods　A total of 152 children with AD were enrolled. The severity of AD was assessed by SCORAD. Serum 25(OH)D levels were determined by liquid chromatography tandem mass spectrometry (LC-MS/MS). The correlation between the severity of AD and serum 25 (OH) D levels was analyzed. Results　In the 152 children (81 males, 71 females) with AD, the median age was 3.5 years. There were 51 cases of mild AD (33.6%), 80 cases of moderate AD (52.6%), and 19 cases of severe AD (12.5%). Vitamin D was sufficient in 55 cases (36.2%), insufficient in 65 cases (42.8%), and deficient in 32 cases (21.1%). The SCORAD score in children with AD was not correlated with serum 25 (OH) D levels (r=?0.047, P=0.567), while positively correlated with total serum IgE (r=0.244, P=0.003) and the percentage of blood eosinophils (r=0.239, P=0.004). Conclusions　Serum vitamin D insufficiency and deficiency were more common in AD children, but the severity of AD was not significantly correlated with serum 25 (OH) D levels.