目的　总结华法林在儿童患者中的应用情况。方法　回顾分析2014年1月至2018年12月接受华法林治疗的 362例患儿的临床资料并进行分析。结果　362例患儿中男性210例、女性152例，平均年龄5.9±4.7岁。患儿主要来源 于心胸外科（194例，53.6%）和心脏内科（125例，34.5%），所患疾病以先天性心脏病（242例，66.9%）和川崎病（74例， 20.4%）为主。主要来自华东地区（262例，72.4%）。 结论　华法林在儿童患者中的应用与成人患者有极大的不同，应特别 关注儿童的抗凝治疗和研究。

Objective　To summarize the application of warfarin in children. Methods　Clinical data of 362 children who used warfarin from January 2014 to December 2018 were collected and retrospectively analyzed. Results　Among the 362 patients treated with warfarin, 210 (58.0%) were male patients and 152 (42.0%) were female patients. Of them 194 (53.6%) came from department of cardiothoracic surgery and 125 (34.5%) came from Department of Cardiology. Diseases needed warfarin therapy were mainly congenital heart disease (242 cases, 66.9%) and Kawasaki disease (74 cases, 20.4%). Pediatric patients treated with warfarin were mainly from East China (262 cases, 72.4%). Conclusion　The use of warfarin in children is very different from that in adults. Children's anticoagulant therapy and research require special attention.