目的　探究影响新生儿毛细血管渗漏综合征（CLS）预后的危险因素。方法　以2010年10月—2019年7月明 确诊断为CLS、入院日龄<28天的新生儿为研究对象，回顾分析存活组与死亡组新生儿的相关临床资料，分析影响新生儿 CLS预后的危险因素。结果　共纳入符合标准的CLS新生儿66例，其中存活46例（69.7%）、死亡20例（30.3%）。 存活组 的出生体质量较死亡组高，低出生体质量儿比例较死亡组低，差异均有统计学意义（P<0.05）；肺出血、消化道出血、高血糖、 高钾血症患病率低于死亡组，差异有统计学意义（P<0.05）。Logistic回归分析显示，肺出血（OR=8.200，95% CI：2.29~29.40， P=0.001）显著增加CLS患儿病死率。结论　肺出血是影响新生儿CLS预后的独立危险因素。

Objective　To explore the risk factors in the prognosis of neonatal capillary leak syndrome (CLS). Methods From October 2010 to July 2019, newborns who were clearly diagnosed with CLS and whose admission age was <28 days were selected as the study subjects. The clinical data of newborns in the survival group and the death group were retrospectively analyzed and the risk factors in the prognosis of CLS were analyzed. Results　In a total of 66 CLS newborns included, 46 (69.7%) survived and 20 (30.3%) died. Compared with the death group, the birth weight of the survival group was higher and the proportion of children with low birth weight was lower, and the differences were statistically significant (P<0.05). The prevalence of pulmonary hemorrhage, gastrointestinal hemorrhage, hyperglycemia and hyperkalemia in the survival group was lower than those in the death group, and the differences were statistically significant (all P<0.05). Logistic regression analysis showed that pulmonary hemorrhage (OR=8.20, 95%CI: 2.29~29.40, P=0.001) significantly increased the mortality of children with CLS. Conclusion　Pulmonary hemorrhage is an independent risk factor for the prognosis of CLS.