目的 总结发生骨折的早产儿代谢性骨病的临床特征。方法 回顾分析2016年1月—2020年4月收治的发生 骨折的6例代谢性骨病新生儿的临床资料。结果 6例新生儿中，男5例、女1例；中位胎龄为27.1周，中位出生体质量900 g。 6 例新生儿中，多发肋骨骨折1例，左肱骨骨折1例，左股骨骨折2例，股骨合并肱骨骨折2例，右肱骨骨折1例。 6例新生儿 的血磷均<1.8 mmol/L，血碱性磷酸酶均>600?IU/L，血钙均在正常范围。 6例新生儿均合并早产儿视网膜病和支气管肺发 育不良， 1例合并坏死性小肠结肠炎。 6例新生儿经积极给予补钙、磷及维生素D3治疗，骨折痊愈出院。结论 极低出生体 质量早产儿需注意避免代谢性骨病合并骨折的发生。

Objective? To?explore?the?clinical?features?of?metabolic?bone?disease?with?fracture?in?preterm?infants.? Method? The?clinical?data?of?metabolic?bone?disease?with?fractures?in?6?neonates?admitted?from?January?2016?to?April?2020?were? retrospectively?analyzed.?Results? Among?the?6?newborns?(5?boys?and?one?girl),?the?median?gestational?age?was?27.1?weeks,? and?the?median?birth?weight?was?900?g.?Among?the?6?newborns,?multiple?costal?fractures?occurred?in?one?case,?left?humeral? fracture?occurred?in?one?case,?left?femoral?fracture?occurred?in?two?cases,?femoral?and?humeral?fracture?occurred?in?two?cases,? and?right?humeral?fracture?occurred?in?one?case.?The?blood?phosphorus?of?the?6?newborns?were?all?<1.8?mmol/L,?and?the?blood? alkaline?phosphatase?were?all?>600?IU/L,?and?the?blood?calcium?were?in?the?normal?range.?All?the?6?neonates?were?complicated? with?retinopathy?of?prematurity?and?bronchopulmonary?dysplasia,?and?one?was?complicated?with?necrotizing?enterocolitis.?After? active?treatment?with?calcium,?phosphorus?and?vitamin?D3,?6?neonates?were?discharged?from?hospital?after?recovery?from?fracture.? Conclusion? Premature?infants?with?very?low?birth?weight?should?pay?attention?to?avoid?metabolic?osteopathy?complicated?with? fracture.