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川崎病诊断相关生物学标志物的研究现状及进展

  • WANG Liang ,
  • SI Ping
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  • 天津市儿童医院检验科(天津 300074)

网络出版日期: 2020-10-10

Status and progress of research in biomarkers for the diagnosis of Kawasaki disease

  • 王亮,司萍
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  • Department of Laboratory Medicine, Tianjin Children's Hospital, Tianjing, 300074

Online published: 2020-10-10

摘要

川崎病(KD)是一种以全身性血管炎为主要病理改变的急性发热出疹性疾病,而冠状动脉损伤(CAL)是KD 最严重的并发症。KD具有季节性、区域性、疾病自限性,以及婴幼儿高发性等特点。早期应用静脉注射免疫球蛋白(IVIG) 能预防大部分患儿发生CAL,但仍有部分患儿对IVIG无反应,并且CAL发生率更高。因此,KD的早期诊断对于减少CAL 以及提高KD患儿生存质量具有重要意义。近年来,许多研究致力于探索KD相关的生物标记物,其中一些已经被证明可 以预测IVIG无反应,而另一些则可能预示CAL发生风险,现综述相关研究现状与进展。

本文引用格式

WANG Liang , SI Ping . 川崎病诊断相关生物学标志物的研究现状及进展[J]. 临床儿科杂志, 2020 , 38(10) : 789 . DOI: 10.3969/j.issn.1000-3606.2020.10.017

Abstract

Kawasaki?disease?(KD)?is?an?acute?febrile?and?rash?disease?with?systemic?vasculitis?as?the?main?pathological? change.?The?coronary?artery?lesion?(CAL)?is?the?most?serious?complication?of?KD.?KD?has?the?characteristics?of?seasonality,? regionality,?self-limitation?and?high?incidence?in?infants?and?young?children.?Early?administration?of?intravenous?immunoglobulin? (IVIG)?can?prevent?the?occurrence?of?CAL?in?most?children.?However,?some?children?are?still?unresponsive?to?IVIG,?and?the? incidence?of?CAL?is?higher.?Therefore,?early?diagnosis?of?KD?is?of?great?significance?for?reducing?CAL?and?improving?the?life? quality?of?KD?children.?This?paper?reviews?the?current?status?and?progress?of?related?research.
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