川崎病（KD）是一种以全身性血管炎为主要病理改变的急性发热出疹性疾病，而冠状动脉损伤（CAL）是KD 最严重的并发症。KD具有季节性、区域性、疾病自限性，以及婴幼儿高发性等特点。早期应用静脉注射免疫球蛋白（IVIG） 能预防大部分患儿发生CAL，但仍有部分患儿对IVIG无反应，并且CAL发生率更高。因此，KD的早期诊断对于减少CAL 以及提高KD患儿生存质量具有重要意义。近年来，许多研究致力于探索KD相关的生物标记物，其中一些已经被证明可 以预测IVIG无反应，而另一些则可能预示CAL发生风险，现综述相关研究现状与进展。

Kawasaki?disease?(KD)?is?an?acute?febrile?and?rash?disease?with?systemic?vasculitis?as?the?main?pathological? change.?The?coronary?artery?lesion?(CAL)?is?the?most?serious?complication?of?KD.?KD?has?the?characteristics?of?seasonality,? regionality,?self-limitation?and?high?incidence?in?infants?and?young?children.?Early?administration?of?intravenous?immunoglobulin? (IVIG)?can?prevent?the?occurrence?of?CAL?in?most?children.?However,?some?children?are?still?unresponsive?to?IVIG,?and?the? incidence?of?CAL?is?higher.?Therefore,?early?diagnosis?of?KD?is?of?great?significance?for?reducing?CAL?and?improving?the?life? quality?of?KD?children.?This?paper?reviews?the?current?status?and?progress?of?related?research.