目的 分析婴儿期胆汁淤积性和非胆汁淤积性肝病的临床特点。方法 回顾分析肝病婴儿的临床资料， 比较胆汁淤积和非胆汁淤积肝病婴儿的临床差异。结果 1 985例肝病婴儿中，男性866例、女性1 119例，入院月龄为 （2 . 88±3 . 08）月。胆汁淤积症婴儿477例（24.0%），非胆汁淤积症婴儿1 508例（76.0%）。单因素分析示，胆汁淤积婴儿 的月龄小于非胆汁淤积婴儿，总胆红素、直接胆红素、γ-谷氨酰转肽酶、碱性磷酸酶、总胆汁酸水平高于非胆汁淤积婴儿， 差异均有统计学意义（P

Objective To explore the clinical characteristics of infantile cholestatic liver diseases and non-cholestatic liver diseases. Methods? The clinical data of liver disease in infants were retrospectively analyzed, and the clinical differences between cholestatic and non-cholestatic liver disease in infants were compared. Results Among 1985 children ( 866 males and 1119 females) aged (2.88±3.088) months at admission, there were 477 cases (24.0%) of cholestasis, and 1 508 cases (76.0%) of non-cholestasis. Univariate analysis showed that the age of cholestasis infants was younger than that in non-cholestasis infants, and the levels of total bilirubin, direct bilirubin, γ-glutamyltranspeptidase, alkaline phosphatase and total bile acid were higher than those in non-cholestasis infants. The differences were statistically significant (all P< 0 . 05 ). Multivariate logistic regression analysis showed that with the higher levels of γ-glutamyltranspeptidase, alkaline phosphatase and total bile acid, the age and albumin level were lower and the possibility of cholestasis was higher. Conclusions Compared with non-cholestatic liver disease in childhood, cholestatic liver disease has earlier onset and higher levels of gamma glutamyltranspeptidase, alkaline phosphatase and total bile acid, which may help the differentiation in clinic.