目的 探讨外周血淋巴细胞亚群和脑脊液蛋白对评估急性期吉兰 -巴雷综合征（GBS）早期疾病严重程度 的意义。方法 回顾分析2011年11月至2020年3月住院确诊的60例GBS患儿的临床资料。根据入院时病情、Hughes量 表评分将患儿分为轻症组和重症组，比较两组患儿的年龄、性别、有无前驱感染以及外周血淋巴细胞亚群、脑脊液蛋白 水平。采用多元logistic回归分析重症GBS发生的危险因素。结果 60例患儿中男33例、女27例，中位年龄5 . 30岁，其 中重症GBS患儿33例（55 %）。重症组外周血CD 3 + 低于轻症组，CD 3 - CD 19 + 、脑脊液总蛋白/微量白蛋白水平均高于轻 症组，差异有统计学意义（P

Objective To investigate the significance of peripheral blood lymphocyte subsets and cerebrospinal fluid protein in evaluating the early stage of acute Guillain-Barré syndrome (GBS) in children. Methods The clinical data of 60 hospitalized children diagnosed with GBS from November 2011 to March 2020 were retrospectively analyzed. The children were divided into mild group and severe group according to the condition at admission and Hughes scale. The age, gender, presence of pre-infection, peripheral blood lymphocyte subsets, and cerebrospinal fluid protein levels between the two groups were compared. Multivariate logistic regression was used to analyze the risk factors of severe GBS. Results Among the 60 children (33 boys and 27 girls, median age=5.30 years), 33 (55%) had severe GBS. Compared with the mild group, the levels of CD3+ in peripheral blood of the severe group were lower, while the levels of CD3- CD19+ and total protein/microalbumin in cerebrospinal fluid were higher, and the differences were statistically significant (P< 0 . 05 ). Multivariate logistic regression analysis showed that the total protein/microalbumin levels in cerebrospinal fluid was a risk factor for severe GBS (P< 0 . 05 ). Conclusions There are disorders of lymphocyte subsets in both mild and severe GBS in the acute stage. Monitoring the levels and classification of cerebrospinal fluid protein in the acute phase of GBS helps assess the severity of the children’s condition.