先天性高位气道阻塞综合征诊治研究进展
Research progress on diagnosis and treatment of congenital high airway obstruction syndrome
Received date: 2021-05-06
Online published: 2022-02-11
先天性高位气道阻塞综合征（CHAOS）是指因胎儿气道完全或接近完全阻塞而引起的十分少见的综合征,包括任何影响胎儿肺部与羊膜腔之间羊水循环的气道阻塞。病因多样,多数为先天发育畸形,也可因外来压迫（如原发颈部包块或双主动脉弓）所致气道梗阻。如产前能及时发现并给予相应的治疗措施,对降低围生期死亡率有很大帮助。目前国内对CHAOS的研究多为个案报道及产前超声筛查方面的研究,基因缺陷相关的研究仍较少,因此形成更加系统的诊断和治疗方案尤为重要。
关键词： 先天性高位气道阻塞综合征; 气道疾病; 新生儿
闫慧源 , 周建国 综述 , 陈超 审校 . 先天性高位气道阻塞综合征诊治研究进展[J]. 临床儿科杂志, 2022 , 40(2) : 149 -154 . DOI: 10.12372/jcp.2022.21e657
Congenital high airway obstruction syndrome (CHAOS) is a rare syndrome caused by complete or nearly complete airway obstruction of the fetus, including any airway obstruction that interrupts the amniotic fluid circulation between the fetal lungs and the amniotic cavity. Its causes are various, most of them are congenital malformations, and airway obstruction can also be caused by external compression (such as primary cervical mass or double aortic arch). If prenatal disorders can be found in time and given corresponding treatments, it is of great help to reduce perinatal mortality. At present, most of the domestic studies on CHAOS are case reports and prenatal ultrasound screening, there are few studies related to gene defects, so it is particularly important to develop a more systematic diagnosis and treatment plan.
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